212688-53-4

Usage

Uses

Used in Pharmaceutical Development:
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-aminopropanoic acid hydrochloride is used as a building block for the synthesis of various peptides and proteins. Its unique structure allows for the creation of complex molecules with specific functions, making it a valuable component in the development of new drugs and therapies.
Used in Cardiovascular Disease Treatment:
In the medical field, (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-aminopropanoic acid hydrochloride is used as a potential treatment for certain cardiovascular diseases. Its role in these treatments is still under investigation, but its potential benefits make it a promising area of study.
Used in Protein-Protein Interaction Studies:
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-aminopropanoic acid hydrochloride is also utilized in research related to protein-protein interactions. Understanding these interactions is crucial for developing a deeper knowledge of cellular processes and can lead to the discovery of new therapeutic targets for various diseases.
Used in Drug Delivery Systems:
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-aminopropanoic acid hydrochloride has been found to play a role in the development of drug delivery systems. Its properties make it a suitable candidate for improving the delivery, bioavailability, and therapeutic outcomes of various drugs, particularly in the context of targeted therapies.

Upstream product

• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 198544-42-2 N^α-(9-fluorenylmethyloxycarbonyl)-N^β-tert-butyloxycarbonyl-D-2,3-diaminopropionic acid 
• 244052-08-2 1-[N-(9-fluorenylmethyloxycarbonyl)-(1S)-amino-2-azidoethyl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane 
• 148150-68-9 1-[N-(9-fluorenylmethyloxycarbonyl)-(1S)-1-amino-2-hydroxyethyl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane 

Downstream Products

• 162558-25-0 N-α-tert-butoxycarbonyl-N-β-(9-fluorenylmethoxycarbonyl)-L-diaminopropionic acid 

Relevant academic research and scientific papers

NITROGEN CONTAINING BICYCLIC COMPOUNDS AND THEIR USE IN TREATMENT OF BACTERIAL INFECTIONS

Compounds of Formula (I), their preparation, and use in preventing or treating a bacterial infection are disclosed.

GLUCOSE-RESPONSIVE INSULIN CONJUGATES

Insulin conjugates comprising an insulin analog molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.

GLUCOSE-RESPONSIVE INSULIN CONJUGATES

Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.

Solid-phase synthesis of amine-bridged cyclic enkephalin analogues via on-resin cyclization utilizing the Fukuyama-Mitsunobu reaction

An efficient solid-phase synthetic route is described for the preparation of 13-membered amine-bridged cyclic enkephalin analogues (ABEs) 1a and 1c-1j (Figure 1) resulting from a sulfonamide-containing peptide whose backbone is bound to a resin. The Fukuyama-Mitsunobu reaction of the 2-nitrobenzenesulfonyl-protected amine bound to the solid support with protected aminoethanol in the presence of triphenylphosphine and diisopropyl azodicarboxylate (DIAD) is utilized to prepare a resin-bound sulfonamide-protected secondary amine. After peptide cyclization, this protected amine functionality becomes the "amine bridge" of the target molecule. In addition, the reagent DIAD was found to be a superior reagent compared to diethyl azodicarboxylate (DEAD) in the solid-phase Fukuyama-Mitsunobu reaction.