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21269-07-8

Benzenesulfonamide, 4-methyl-N-[(2-pyridinylamino)carbonyl]-, also known as Sulfasalazine, is a chemical compound with the molecular formula C18H15N3O5S. It is a prodrug, primarily used in the treatment of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. Sulfasalazine consists of a sulfapyridine molecule attached to a 5-aminosalicylic acid (5-ASA) molecule through an azo bond. In the body, it is metabolized into its active components, sulfapyridine and 5-ASA, which exhibit anti-inflammatory and antibacterial properties, respectively. The drug's mechanism of action is not fully understood, but it is believed to involve the inhibition of nuclear factor kappa B (NF-kB) and the reduction of inflammation in the gastrointestinal tract.

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  • 21269-07-8 Structure

  • Basic information

    1. Product Name: Benzenesulfonamide, 4-methyl-N-[(2-pyridinylamino)carbonyl]-
    2. Synonyms:
    3. CAS NO:21269-07-8
    4. Molecular Formula: C13H13N3O3S
    5. Molecular Weight: 291.331
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 21269-07-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Benzenesulfonamide, 4-methyl-N-[(2-pyridinylamino)carbonyl]-(CAS DataBase Reference)
    10. NIST Chemistry Reference: Benzenesulfonamide, 4-methyl-N-[(2-pyridinylamino)carbonyl]-(21269-07-8)
    11. EPA Substance Registry System: Benzenesulfonamide, 4-methyl-N-[(2-pyridinylamino)carbonyl]-(21269-07-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 21269-07-8(Hazardous Substances Data)

21269-07-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 21269-07-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,2,6 and 9 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 21269-07:
(7*2)+(6*1)+(5*2)+(4*6)+(3*9)+(2*0)+(1*7)=88
88 % 10 = 8
So 21269-07-8 is a valid CAS Registry Number.

21269-07-8Relevant articles and documents

Novel agents effective against solid tumors: The diarylsulfonylureas. Synthesis, activities, and analysis of quantitative structure-activity relationships

Howbert,Grossman,Crowell,Rieder,Harper,Kramer,Tao,Aikins,Poore,Rinzel,Grindey,Shaw,Todd

, p. 2393 - 2407 (2007/10/02)

A series of diarylsulfonylureas with exceptionally broad-spectrum activity against syngeneic rodent solid tumors in vivo is described. Their discovery resulted from a program dedicated to in vivo screening for novel oncolytics in solid tumor models, rather than traditional ascites leukemia models. The structures, oral efficacy, side-effect profile, and mechanism of action of these sulfonylureas appear to be distinct from previously known classes of oncolytics. An extensive series of analogues was prepared to probe structure-activity relationships (SAR), with particular focus on the substituent patterns of each aryl domain. Quantitative analysis of these substituent SARs, using the method of cluster significance analysis, showed the lipophilicity of the substituents to be the dominant determinant of activity. One compound from the series, LY186641 (104, sulofenur), has progressed to Phase I clinical trials as an antitumor drug.

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