21269-13-6

Basic information

• Product Name: 21-hydroxy-2'-methyl-16beta-5'H-pregn-4-eno[17,16-d]oxazole-3,20-dione 21-acetate
• Synonyms: 21-hydroxy-2'-methyl-16beta-5'H-pregn-4-eno[17,16-d]oxazole-3,20-dione 21-acetate;(16β)-21-Acetyloxy-2'-methylpregnano[17,16-d]oxazol-4-ene-3,20-dione;Einecs 244-306-4
• CAS NO: 21269-13-6
• Molecular Formula: C₂₅H₃₃NO₅
• Molecular Weight: 427.53322
• EINECS: 244-306-4
• Mol File: 21269-13-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 555.7°Cat760mmHg
• Flash Point: 200.3°C
• Appearance: /
• Density: 1.36g/cm³
• PKA: 4.13±0.70(Predicted)
• CAS DataBase Reference: 21-hydroxy-2'-methyl-16beta-5'H-pregn-4-eno[17,16-d]oxazole-3,20-dione 21-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 21-hydroxy-2'-methyl-16beta-5'H-pregn-4-eno[17,16-d]oxazole-3,20-dione 21-acetate(21269-13-6)
• EPA Substance Registry System: 21-hydroxy-2'-methyl-16beta-5'H-pregn-4-eno[17,16-d]oxazole-3,20-dione 21-acetate(21269-13-6)

Safety Data

• Hazardous Substances Data: 21269-13-6(Hazardous Substances Data)

Usage

Type

Synthetic chemical compound

Derivative of

Progesterone

Class

Oxazole steroids

Contains

Hydroxy group at 21st position
Methyl group at 2' position
Acetate group at 21st position
Potential pharmaceutical applications
Used as a synthetic intermediate in production of steroid medications
Suitable for further modification and manipulation for creating specific pharmaceuticals with targeted biological activities

Upstream product

• 96700-71-9 <17,16a-d>-2'-methyloxazoline derivative of 20,20-dimethoxypregn-5-ene-3β,21-diol 
• 96700-73-1 <17,16a-d>-2'-methyloxazoline derivative of 3β,21-dihydroxypregn-5-en-20-one 
• 14022-55-0 <17,16a-d>-2'-methyloxazoline derivative of 3β-hydroxypregn-5-en-20-one 
• 85959-16-6 <17,16a-d>-2'-methyloxazoline derivative of 21-acetoxy-3β-hydroxypregn-5-en-20-one 

Relevant articles and documents

TRANSFORMED STEROIDS. IODOSOBENZENE DIACETATE FOR THE α-HYDROXYLATION OF -2'-METHYLOXAZOLINE DERIVATIVES OF 20-KETOSTEROIDS

Using the -2'-methyloxazoline derivatives of 3β-hydroxypregn-5-en-20-one (I) as an example, the α-hydroxylation reaction has been studied with the use of iodosobenzene diacetate in a methanolic solution of NaOH as the α-hydroxylating reagent.The reaction took place successfully through the stage of the formation and isolation of the corresponding -2'-methyloxazoline derivative of 20,20-dimethylpregn-15-ene-3β,21-diol (II), the dimethyl acetal protection of which was eliminated by acid hydrolysis in methanol.The results of physicochemical investigations and biological trials of the -2'-methyloxazoline derivatives of 21-hydroxy-21-acetoxy-20-ketosteroids obtained are given.