2127-05-1

Basic information

• Product Name: 4-Pyridylethylmercaptan
• Synonyms: 4-pyridoethanethiol;2-(4''-PYRIDYL) ETHANETHIOL,=98.0%;2-(4-Pyridyl)ethanethiol;4-Pyridylethylmercaptan;2-(4-PYRIDYL)ETHANETHIOL (4-MERCAPTOETHYL PYRIDINE HYDROCHLORIDE);2-PYRIDIN-4-YL-ETHANTHIOL;2-(4-Pyridinyl)ethanethiol;2-(Pyridine-4-yl)ethanethiol
• CAS NO: 2127-05-1
• Molecular Formula: C₇H₉NS
• Molecular Weight: 139.22
• Product Categories: Aromatics;Heterocycles;Sulfur & Selenium Compounds
• Mol File: 2127-05-1.mol

Chemical Properties

• Boiling Point: 247.1°Cat760mmHg
• Flash Point: 103.3°C
• Appearance: /
• Density: 1.074g/cm³
• Vapor Pressure: 0.041mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: Amber Vial, Refrigerator, Under Inert Atmosphere
• CAS DataBase Reference: 4-Pyridylethylmercaptan(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridylethylmercaptan(2127-05-1)
• EPA Substance Registry System: 4-Pyridylethylmercaptan(2127-05-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 2127-05-1(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Liquid

InChI:InChI=1/C7H9NS/c9-6-3-7-1-4-8-5-2-7/h1-2,4-5,9H,3,6H2

Upstream product

• 100-43-6 4-vinylpyridine 
• 17356-08-0 thiourea 
• 6298-11-9 4-(2-mercaptoethyl)pyridinium hydrochloride 

Downstream Products

• 78092-91-8 2-((2-(pyridin-4-yl)ethyl)thio)ethan-1-ol 
• 163009-34-5 diphenylmethyl 7β-[2-(Z)-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[2-(4-pyridyl)ethylthio]-3-cephem-4-carboxylate 
• 81488-28-0 (5R,6R)-6-Ethyl-7-oxo-3-(2-pyridin-4-yl-ethylsulfanyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Relevant articles and documents

On the pH-Modulated Ru-Based Prodrug Activation Mechanism

The RuIII-based prodrug AziRu efficiently binds to proteins, but the mechanism of its release is still disputed. Herein, in order to test the hypothesis of a reduction-mediated Ru release from proteins, a Raman-assisted crystallographic study on AziRu binding to a model protein (hen egg white lysozyme), in two different oxidation states, RuII and RuIII, was carried out. Our results indicate Ru reduction, but the Ru release upon reduction is dependent on the reducing agent. To better understand this process, a pH-dependent, spectroelectrochemical surface-enhanced Raman scattering (SERS) study was performed also on AziRu-functionalized Au electrodes as a surrogate and simplest model system of RuII- and RuIII-based drugs. This SERS study provided a pKa of 6.0 ± 0.4 for aquated AziRu in the RuIII state, which falls in the watershed range of pH values separating most cancer environments from their physiological counterparts. These experiments also indicate a dramatic shift of the redox potential E0 by >600 mV of aquated AziRu toward more positive potentials upon acidification, suggesting a selective AziRu reduction in cancer lumen but not in healthy ones. It is expected that the nature of the ligands (e.g., pyridine vs imidazole, present in well-known RuIII complex NAMI-A) will modulate the pKa and E0, without affecting the underlying reaction mechanism.

METHOD FOR PRODUCING BISPHENOL COMPOUND

Phenol compound and a carbonyl compound with strong cation exchange and 2-(2-mercaptoacetyl cop toe ethyl) pyridine in the presence of manufacturing method as bisphenol compounds, said phenol compound and a carbonyl compound causes the concentration of water in reaction material including 0.05 to 0.5 weight % provided that the manufacturing method characterized by bisphenol compounds.

PROCESS FOR PREPARING BISPHENOL

Provided is a process for producing a bisphenol compound stably at a high conversion and with high selectivity over a long period. A process for producing a bisphenol compound by feeding a phenol compound and a carbonyl compound continuously to a reactor packed with an acid catalyst, characterized in that the acid catalyst is a sulfonic-acid-form cation-exchange resin in which part of the sulfo groups have been modified with at least any one of 2-pyridylalkanethiol compounds and 3-pyridylalkanethiol compounds.

Process for producing pyridylethylthio compound, modified ion exchanger and process for producing the same, and process for producing bisphenol compound

The present invention relates to a process for producing a pyridylethylthio compound which is improved in yield of the pyridylethylthio compound. In a process for producing a pyridylethylthio compound by reacting vinyl pyridine with a sulfur-containing compound, vinyl pyridine used contains a compound represented by the general formula (1): (wherein R1 and R2 are any of combination of isopropenyl group and a hydrogen atom, combination of 1-propenyl group and a hydrogen atom, combination of 2-propenyl group and a hydrogen atom, and combination of methyl group and vinyl group), in an amount of not more than 4% by weight.

Process for producing 2-(4-pyridyl)ethanethiol

An object of the present invention is to provide a process for producing 2-(4-pyridyl)ethanethiol easily. According to the invention, 4-vinylpyridine is reacted with thiourea in an aqueous medium containing an acid to form a solution containing an isothiuronium salt and then the solution is made alkaline to convert the isothiuronium salt into 2-(4-pyridyl)ethanethiol.

PROCESS FOR PRODUCING OMEGA-MERCAPTOALKYLPYRIDINE

The present invention provides a process for producing ω-mercaptoalkylpyridine of the formula (II) wherein R1 and R2 each independently represent hydrogen or methyl, and n represents an integer of 0 to 2, comprising reacting pyridine compound of the formula (I) wherein R1, R2 and n have the same meanings described above, and hydrogen sulfide in the presence of tertiary amine.

ACTIVITE ESTEROLYTIQUE DE COMPOSES ASSOCIANT UNE FONCTION THIOL ET UNE BASE HETEROCYCLIQUE. EXEMPLES DE PROCESSUS BIFONCTIONNEL

The synthesis of 19 compounds associating a thiol function and a basic heterocycle (i.e. benzimidazole, pyridine, thiazole) is described.Their esterolytic activity towards para nitrophenyl acetate (PNPA) is compared with that of simple monofunctional thiols.The influence of the substituents and of the nature of the basic heterocycle shows that the apparition of a cooperative effect depends both on the relative pKa values (thiol and heterocyclic) and on the possibility of proton exchange via the heterocyclic moiety.Examples of bifonctional process are reported in the case of benzimidazolylmethanethiol compounds, due to a basic assistancce on the neutral form of the thiol function.