212758-02-6

Basic information

• Product Name: Benzeneacetic acid, alpha-amino-3,5-dihydroxy-4-methoxy-, (alphaS)- (9CI)
• Synonyms: Benzeneacetic acid, alpha-amino-3,5-dihydroxy-4-methoxy-, (alphaS)- (9CI)
• CAS NO: 212758-02-6
• Molecular Formula: C9H11NO5
• Molecular Weight: 213.18734
• Product Categories: ALCOHOL
• Mol File: 212758-02-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzeneacetic acid, alpha-amino-3,5-dihydroxy-4-methoxy-, (alphaS)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, alpha-amino-3,5-dihydroxy-4-methoxy-, (alphaS)- (9CI)(212758-02-6)
• EPA Substance Registry System: Benzeneacetic acid, alpha-amino-3,5-dihydroxy-4-methoxy-, (alphaS)- (9CI)(212758-02-6)

Safety Data

• Hazardous Substances Data: 212758-02-6(Hazardous Substances Data)

Upstream product

• 203504-54-5 (R)-(+)-N-(3,5-diisopropoxy-4-methoxybenzylidene)-p-toluenesulfinamide 
• 203504-58-9 4-Methyl-benzenesulfinic acid [(R)-cyano-(3,5-diisopropoxy-4-methoxy-phenyl)-methyl]-amide 
• 203504-55-6 4-Methyl-benzenesulfinic acid 1-(3,5-bis-benzyloxy-4-methoxy-phenyl)-meth-(Z)-ylideneamide 
• 171738-30-0 methyl 3,5-diisopropoxy-4-methoxybenzoate 
• 171738-31-1 4-methoxy-3,5-diisopropyloxybenzaldehyde 
• 203504-59-0 4-Methyl-benzenesulfinic acid [(R)-(3,5-bis-benzyloxy-4-methoxy-phenyl)-cyano-methyl]-amide 
• 24093-81-0 methyl 3,5-dihydroxy-4-methoxybenzoate 
• 13326-69-7 methyl 3,5-bis(benzyloxy)-4-methoxybenzoate 
• 13326-72-2 3,5-bis(benzyloxy)-4-methoxybenzaldehyde 
• 191542-07-1 (2R)-2-azido-2-[3,5-bis(benzyloxy)-4-methoxyphenyl]ethanoic acid 
• 212757-95-4 (3,5-Diisopropoxy-4-methoxy-phenyl)-(2,2,2-trifluoro-acetylamino)-acetic acid methyl ester 
• 212757-98-7 (3,5-Dihydroxy-4-methoxy-phenyl)-(2,2,2-trifluoro-acetylamino)-acetic acid methyl ester 
• 1026696-96-7 Amino-(3,5-diisopropoxy-4-methoxy-phenyl)-acetonitrile 
• 212758-01-5 (3,5-Dihydroxy-4-methoxy-phenyl)-(2,2,2-trifluoro-acetylamino)-acetic acid 

Relevant articles and documents

Chemoenzymatic synthesis of D-N-Boc-3,5-dihydroxy-4- methoxyphenylglycine

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Expeditious syntheses of two arylglycine derivatives corresponding to the central amino acid of the vancomycin family of antibiotics

Two expeditious and efficient syntheses (in 7 and 4 steps, respectively) are described for the central amino acid part of the vancomycin family. The first method constitutes a concise asymmetric synthesis, starting from 4- hydroxyphenylacetic acid, of (R)-(3,5-dihydroxy-4-methoxyphenyl)glycine derivatives using Evans' asymmetric azidation methodology. In the second approach, an efficient synthesis of a protected 3,5-dichloro-4- methoxyphenylglycine derivative is described, starting from commercially available (R)-4-hydroxyphenylglycine. These two syntheses are much shorter and operationally simpler than those previously described, and are currently employed in an effort towards the construction of the bicyclic system of vancomycin and ristocetin.