212782-80-4

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 212782-78-0 5-amino-2-phenyl-1-pentene 
• 93222-37-8 4-phenylpent-4-en-1-ol 
• 212782-77-9 4-phenylpent-4-en-1-yl methanesulfonate 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 86043-10-9 2-(4-phenyl-4-pentenyl)-1H-isoindole-1,3(2H)-dione 

Relevant academic research and scientific papers

Base-Mediated Intramolecular Decarboxylative Synthesis of Alkylamines from Alkanoyloxycarbamates

A general and effective method for the synthesis of alkylamine via intramolecular decarboxylation of alkanoyloxycarbamates is described. The alkanoyloxycarbamates are readily prepared with alkyl carboxylic acids and hydroxylamine. The reaction shows a broad range of substrates (primary and secondary alkyl) with functional tolerance, and the corresponding products were obtained in good yields under mild conditions.

Chiral diselenides in asymmetric cyclization reactions

The use of chiral selenium electrophile 6 generated in situ from the chiral diselenide 5 in asymmetric ring closure reactions of unsaturated alcohols, carboxylic acids and carbamates is presented herein. Tetrasubstituted carbon atoms can be generated selectively with diastereoselectivities up to 85% when geminal disubstituted alkenes are used. The cyclization of vinylic silanes leads to versatile building blocks for further synthetic transformations.