21280-45-5Relevant academic research and scientific papers
Iodine-catalyzed coupling of β-hydroxyketones with aromatic amines to form β-aminoketones and Benzo[h]quinolones
Miao, Changqing,Jiang, Liya,Ren, Lanhui,Xue, Qingxia,Yan, Fang,Shi, Weiwei,Li, Xinjian,Sheng, Jiwen,Kai, Shuangshuang
, p. 2215 - 2228 (2019)
An iodine-catalyzed coupling of β-hydroxyketones with aromatic amines to yield β-aminoketones and benzo[h]quinolones had been developed. Noble metallic catalysts, oxidants, α β-unsaturated ketone intermediates and aza-Michael addition were not involved in this coupling reaction which made it unique when compared to other reactions reported in literature. Inexpensive iodine catalyst, easy accessible raw materials, mild reaction conditions, good functional group tolerance and excellent selectivity made this coupling reaction be a practical method. This reaction can also be scaled up.
Synthesis of Heterocyclic Compounds: Part XXVI - 3,6-Diaryl-3,4-dihydro-1,3,2-oxazaphosphorin-2-oxides
Modak, A. S.,Gogte, V. N.,Tilak, B. D.
, p. 907 - 913 (2007/10/02)
3,4-Dihydro-1,3,2-oxazaphosphorin-2-oxides (4a-r) have been prepared by the interaction of aryl β-aryl/alkylaminoethyl ketones (3a-r) with POCl3/Et3N.Various reactions of these compounds, which represent a new ring system, are reported.Few of these compou
Synthesis and Reactions of 3,6-Diaryl-3,4-dihydro-1,3,2-oxazaphosphorin-2-oxides
Tilak, B. D.,Gogte, V.N.,Modak, A.S.
, p. 414 - 415 (2007/10/02)
Aryl β-arylaminoethyl ketones (1), when reacted with phosphorus oxychloride followed by treatment with triethylamine, afford 3,6-diaryl-2-chloro-3,4-dihydro-1,3,2-oxazaphosphorin-2-oxides (3a-u), a hitherto unreported ring system.The oxazaphosphorin (3q), viz. 2-chloro-3-m-anisyl-6-phenyl-3,4-dihydro-1,3,2-oxazaphosphorin, is converted into 7-methoxy-4-phenylquinoline on keeping.This transformation is specific to 3q since other oxazaphosphorins fail to give the quinoline derivative.
