212844-54-7 Usage
Uses
Used in Pharmaceutical Industry:
(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol is used as a cyclin-dependent kinase (CDK) inhibitor for cancer therapy. Cyclin-dependent kinases are key regulators of cell cycle progression, and their inhibition can lead to the arrest of cancer cell growth and proliferation. (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol has shown potent inhibitory activity against several CDKs, including Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B, with IC50 values in the nanomolar range.
Used in Antiviral Applications:
(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol is used as an antiviral agent, particularly against Plasmodium parasites, which are responsible for malaria. At micromolar doses, (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol has demonstrated the ability to inhibit the growth of these parasites, offering a potential therapeutic approach for the treatment of malaria and other parasitic infections.
Biological Activity
Cyclin-dependent kinase inhibitor. IC 50 values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Selective over a range of other protein kinases (IC 50 > 10,000 nM). Shown to have antiproliferative properties, mediated by p42/p44 MAPK.
Check Digit Verification of cas no
The CAS Registry Mumber 212844-54-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,2,8,4 and 4 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 212844-54:
(8*2)+(7*1)+(6*2)+(5*8)+(4*4)+(3*4)+(2*5)+(1*4)=117
117 % 10 = 7
So 212844-54-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H25ClN6O3/c1-10(2)15(8-28)24-20-25-17(16-18(26-20)27(9-22-16)11(3)4)23-12-5-6-13(19(29)30)14(21)7-12/h5-7,9-11,15,28H,8H2,1-4H3,(H,29,30)(H2,23,24,25,26)/t15-/m0/s1
