212846-71-4Relevant academic research and scientific papers
Straightforward Synthesis of α-Chloromethylketimines Catalyzed by Gold(I). A Clean Way to Building Blocks
Asensio, Gregorio,Cárcel, María,Olmos, Andrea,Ramírez De Arellano, Carmen,Sarmiento, Jeymy T.,Varea, Teresa
supporting information, p. 3114 - 3122 (2022/03/14)
α-Chloromethylketimines have been obtained through a gold-catalyzed hydroamination of aromatic and aliphatic 1-chloroalkynes with aromatic amines by using equimolar amounts of both reagents. This procedure has allowed the preparation and spectroscopic characterization of α-chloromethylketimines for the first time with a high degree of purity, complete conversion, and atom economy. The synthetic usefulness of the methodology has been demonstrated with the preparation of β-chloroamines and indoles.
Method for preparing 1-halogenated alkyne under catalysis of heterogeneous Ag catalyst at room temperature
-
Paragraph 0023-0036; 0043, (2021/05/12)
The invention discloses a novel method for preparing 1-halogenated alkyne under the catalysis of a heterogeneous Ag catalyst at room temperature. The method comprises the steps of mixing terminal alkyne compounds containing different substituent groups, N
Highly efficient and recyclable catalyst for the direct chlorination, bromination and iodination of terminal alkynes
Shi, Wei,Guan, Zhipeng,Cai, Peng,Chen, Hao
, p. 199 - 204 (2017/08/10)
Direct halogenation, including chlorination, bromination and iodination of terminal alkynes, are of great importance in organic synthesis. Here an efficient and recyclable nano-Ag/g-C3N4 catalyst system was developed and proved to be remarkably active with 39 examples varied from chlorination, bromination to iodination, of which 14 runs have yielded more than 95% of the product. Recycling of the catalyst was also achieved without obvious activity loss after several runs: 99% yield was observed even after 5 runs in the bromination of phenylacetylene. The catalysts system is of low cost and easy to be prepared, making this procedure versatile, convenient and economic.
Elusive ethynyl azides: Trapping by 1,3-dipolar cycloaddition and decomposition to cyanocarbenes
Banert, Klaus,Hagedorn, Manfred,Wutke, Jens,Ecorchard, Petra,Schaarschmidt, Dieter,Lang, Heinrich
supporting information; experimental part, p. 4058 - 4060 (2010/09/06)
Although they decompose rapidly to produce cyanocarbenes, ethynyl azides were generated from (chloroethynyl)arenes and trapped for the first time by 1,3-dipolar cycloaddition at cyclooctyne.
