212851-51-9Relevant academic research and scientific papers
Oxazaborolidine-mediated asymmetric reduction of 1,2-diaryl-2- benzyloxyiminoethanones and 1,2-diarylethanediones
Shimizu, Makoto,Tsukamoto, Keiko,Matsutani, Takayuki,Fujisawa, Tamotsu
, p. 10265 - 10274 (1998)
Highly enantioselective reduction of 1,2-diaryl-2- benzyloxyiminoethanones and 1,2-diarylethanediones was conducted using oxazaborolidine derived from L-threonine and borane complexes to give β- imino alcohols and 1,2-diaryl-1,2-ethanediols in high enantiomeric purity. Subsequent reduction of the imino functionality of the former products afforded either syn- or anti-2-amino-1,2-diarylethanols in high enantiomeric purity by choosing appropriate reduction methods.
Preparation of optically pure (1r,2s)- and (1s,2r)-di-p-methoxyphenyl amino alcohol
Liao, Jian,Zhang, Yili,Li, Zhi,Chen, Daimo,Chan, Albert S. C.
, p. 3465 - 3472 (2007/10/03)
Racemic di-p-methoxyphenyl amino alcohol was synthesized in three steps. Optically pure di-p-methoxyphenyl amino alcohols were obtained by recrystallization. The absolute configuration of the amino alcohol was determined by X-ray crystallography.
Stereodivergent approach to syn- and anti 2-amino-1,2-diarylethanols using oxazaborolidine-mediated asymmetric reduction
Shimizu, Makoto,Tsukamoto, Keiko,Fujisawa, Tamotsu
, p. 5193 - 5196 (2007/10/03)
Highly enantioselective reduction of 1,2-diaryl-2-benzyloxyiminoethanones was conducted using oxazaborolidine derived from L-threonine and BH3· SMe2 to give β-imino alcohols in high enantiomeric purity. Subsequent reduclion of the imino functionality afforded either syn- or anti-2-amino-1,2-diarylethanols in high enantiomeric purity by choosing appropriate reduction conditions.
