21290-71-1

Usage

Uses

Used in Perfumery:
2-(prop-2-yn-1-yl)cyclohexan-1-ol is used as a fragrance ingredient for its sweet, floral scent, contributing to the creation of various perfumes and fragrances.
Used in Organic Synthesis:
2-(prop-2-yn-1-yl)cyclohexan-1-ol is used as a chemical intermediate in the synthesis of other compounds. Its propargyl group allows for the formation of various carbon-carbon and carbon-heteroatom bonds, making it a versatile building block in organic chemistry.
Used in Pharmaceutical Industry:
2-(prop-2-yn-1-yl)cyclohexan-1-ol is used as a chemical intermediate in the development of pharmaceuticals. Its reactivity and structural features make it a valuable compound for the synthesis of new drug molecules.
Used in Research and Development:
2-(prop-2-yn-1-yl)cyclohexan-1-ol is used in research and development settings to explore its potential applications and properties, further expanding its utility in various fields.

Upstream product

• 19823-75-7 2-(2-propynyl)cyclohexanone 
• 18295-60-8 propargyl magnesium bromide 
• 286-20-4 cyclohexane-1,2-epoxide 
• 108-94-1 cyclohexanone 

Downstream Products

• 21197-59-1 2-(3-Acetylmercaptoallyl)-cyclohexanol 

Relevant academic research and scientific papers

Bismuth(iii)-catalyzed cycloisomerization and (hetero)arylation of alkynols: Simple access to 2-(hetero)aryl tetrahydrofurans and tetrahydropyrans

2-(Hetero)aryl tetrahydrofurans and tetrahydropyrans were successfully synthesized using Bi(OTf)3-catalyzed hydroalkoxylation (cycloisomerization) of alkynols (via 5 or 6 exo-dig cyclization) and intermolecular (hetero)arylation. This reaction involves a highly efficient cascade process, where initially the alkynol undergoes a cycloisomerization step via activation of the triple bond and generates the oxocarbenium ion, which subsequently participates in the (hetero)hydroarylation step with electron-rich arenes. Simple to complex suitably functionalized alkynols (4-pentyn-1-ols and 5-hexyn-1-ols) and electron-rich aromatic compounds were found to be reliable substrates in this cascade transformation and furnished a wide range of oxygen heterocycles. This practical tandem process provides a means to build libraries related to pharmacologically active molecules and natural product like scaffolds.

Synthesis of 5-Iodo-1,2,3,4-tetrahydropyridines by Rhodium-Catalyzed Tandem Nucleophilic Attacks Involving 1-Sulfonyl-1,2,3-triazoles and Iodides

Sodium iodide is used for the first time as a nucleophile to trap an α-imino rhodium carbene, which triggers a tandem process involving intermolecular nucleophilic attack and intramolecular SN2 reaction. A series of 5-iodo-1,2,3,4-tetrahydropyridines are obtained in high yield, and the synthetic utility of the products is demonstrated in cross-coupling reactions and the construction of biorelated polycyclic compounds.