212914-74-4

Basic information

• Product Name: 2-Pyridinecarboxaldehyde,4-(hydroxymethyl)-(9CI)
• Synonyms: 2-Pyridinecarboxaldehyde,4-(hydroxymethyl)-(9CI);2-Pyridinecarboxaldehyde, 4-(hydroxyMethyl)-;4-(hydroxyMethyl)picolinaldehyde;4-(hydroxymethyl)-2-Pyridinecarboxaldehyde;4-(Hydroxymethyl)pyridine-2-carbaldehyde
• CAS NO: 212914-74-4
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 137.13598
• Product Categories: PYRIDINE
• Mol File: 212914-74-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Pyridinecarboxaldehyde,4-(hydroxymethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxaldehyde,4-(hydroxymethyl)-(9CI)(212914-74-4)
• EPA Substance Registry System: 2-Pyridinecarboxaldehyde,4-(hydroxymethyl)-(9CI)(212914-74-4)

Safety Data

• Hazardous Substances Data: 212914-74-4(Hazardous Substances Data)

Usage

Uses

4-(Hydroxymethyl)-2-pyridinecarboxaldehyde is a reactant that has been used in the preparation of edotecarin analogues as potent topoisomerase I inhibitors with cytotoxic (CTX) activities against MKN-45 human stomach cancer or MX-1 human breast cancer.

Upstream product

• 499-80-9 pyridine-2,4-dicarboxylic acid 
• 41438-38-4 diethyl pyridine-2,4-dicarboxylate 

Relevant articles and documents

Selective DIBAL-H Monoreduction of a Diester Using Continuous Flow Chemistry: From Benchtop to Kilo Lab

Herein we report a selective DIBAL-H-mediated reduction of a heterocyclic diester to the corresponding monoaldehyde using continuous flow chemistry. The use of continuous flow enabled operation at lower temperatures and better control of the reaction time, thereby allowing for a significant increase in reaction selectivity and yield compared with batch conditions. The reaction's development as a continuous flow process and its scale-up from laboratory gram scale to multikilogram scale are discussed, including design of experiments studies to probe the optimal reaction window.