212970-89-3Relevant academic research and scientific papers
Convenient synthesis of deuterated glutamic acid, proline and leucine via catalytic deuteration of unsaturated pyroglutamate derivatives
Oba, Makoto,Ohkuma, Kosuke,Hitokawa, Hiroshi,Shirai, Ayumi,Nishiyama, Kozaburo
, p. 229 - 235 (2007/10/03)
Novel 3,4-didehydropyroglutamate derivatives, the key intermediates in this synthesis, were obtained from a protected pyroglutamate by the well-known selenenylation-oxidative deselenenylation method and were catalytically deuterated using a slow-addition technique. The obtained deuterated pyroglutamates were converted to [3,4-2H2]glutamic acid, [3,4,5-2H3]proline, and [3,4,5,5,5-2H 5]leucine via an appropriate functional group interconversions followed by the standard deprotection procedure. Copyright
