213118-58-2

Upstream product

• 96-96-8 4-methoxy-2-nitroaniline 
• 185428-90-4 (4-methoxy-2-nitro-phenyl)-carbamic acid tert-butyl ester 
• 213118-56-0 (2-amino-4-methoxyphenyl)carbamate tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 624-83-9 methyl isocyanate 
• 213118-57-1 1-(N-methyl)-2-(N-tert-butoxycarbonyl)-4-methoxy-1,2-phenylenediamine 

Downstream Products

• 213118-59-3 1-(2-Amino-5-methoxy-phenyl)-1,3-dimethyl-urea 

Relevant academic research and scientific papers

Synthesis and stability of 5-, 7- and 8-substituted benzo-1,2,3,5-tetrazepin-4-ones

In order to determine the effect of substituents on the stability of benzo-fused 1,2,3,5-tetrazepin-4-ones, 5-, 7- and 8-substituted derivatives (6a-d), and (10) were synthesized. The stability of the tetrazepinones increased with the electron withdrawing character of the substituents at the benzene ring. Bulky groups at the 5 position destabilize the tetrazepinone ring. The unstable tetrazepinones (6b, 10 and 14) decomposed in chloroform at room temperature to benzotriazole derivatives (11, 12 and 15). X-Ray diffraction of nitrobenzotetrazepinone (6d) showed that despite the elctron withdrawing effect of the nitro group para to the triazene chain, N3 exhibited a significant pyramidal character. In 6d, the 1,2,3,5-tetrazepinone cycle has an almost perfect seven-membered ring boat shape.