21313-45-1Relevant academic research and scientific papers
PEPTIDE SYNTHESIS BY USING PHENYLPHOSPHONIC ESTER AS A COUPLING REAGENT
Watanabe, Yutaka,Morito, Naoya,Kamekawa, Ken-ichi,Mukaiyama, Teruaki
, p. 65 - 68 (2007/10/02)
Synthesis of peptides containing various functions was efficiently accomplished by treatment of the tetrabutylammonium salts of N-protected amino acids (or peptides) with amino acid esters in the presence of bis(o- or p-nitrophenyl) phenylphosphonate.Synthesis of leucine-enkephalin was successfully achieved by the above method employing a (3+2) or (4+1) fragment coupling approach.
