213132-41-3

Upstream product

• 516-12-1 N-iodo-succinimide 
• 91704-05-1 (2S)-2-[N-trifluoroacetyl-N-((R)-phenylethyl)aminomethyl]-3,4-dihydro-2H-pyran 

Downstream Products

• 213132-49-1 N-[(2S,5S,6R)-6-((3aR,4S,6S,7R,7aR)-6-Azido-4-methoxy-3-methyl-2-oxo-octahydro-benzooxazol-7-yloxy)-5-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-tetrahydro-pyran-2-ylmethyl]-2,2,2-trifluoro-N-((R)-1-phenyl-ethyl)-acetamide 
• 213132-45-7 ({[(1S,2R,3R,4S,6S)-4-Azido-2-hydroxy-6-methoxy-3-((2R,6S)-6-{[methyl-((R)-1-phenyl-ethyl)-amino]-methyl}-5,6-dihydro-2H-pyran-2-yloxy)-cyclohexyl]-methyl-carbamoyl}-methyl)-carbamic acid benzyl ester 
• 213132-43-5 (3aR,4S,6S,7R,7aR)-6-Azido-7-((2R,3S,6S)-3-iodo-6-{[methyl-((R)-1-phenyl-ethyl)-amino]-methyl}-tetrahydro-pyran-2-yloxy)-4-methoxy-3-methyl-hexahydro-benzooxazol-2-one 
• 213132-44-6 (1R,2R,3S,5S,6S)-3-Azido-5-methoxy-6-methylamino-2-((2R,6S)-6-{[methyl-((R)-1-phenyl-ethyl)-amino]-methyl}-5,6-dihydro-2H-pyran-2-yloxy)-cyclohexanol 
• 213132-42-4 (3aR,4S,6S,7R,7aR)-6-Azido-7-{(2R,3S,6S)-3-iodo-6-[((R)-1-phenyl-ethylamino)-methyl]-tetrahydro-pyran-2-yloxy}-4-methoxy-3-methyl-hexahydro-benzooxazol-2-one 

Relevant academic research and scientific papers

Sannamycin-type aminoglycoside antibiotics - Efficient syntheses - Biological activity

Shorter and more efficient routes to 6′-des(N-methyl)sannamycin A (1) and its 2′-epi analog 2 have been elaborated with the proven sannamine-type acceptor 10 and the glycosyl donors 5-8 featuring novel protecting patterns. With glycal 9 as glycosyl donor (and 10) an expedient access to 2′-desamino- (3) and 2′-desamino-2′-epi-hydroxysannamycin A (4) has been opened. For 4 a modest antibacterial activity was found, while 3 was inactive.