2131803-90-0 Usage
Description
Ethyl 2-((4,4-dimethyl-1-oxothiochroman-6-yl)ethynyl)pyrimidin-5-carboxylate is a complex organic compound with a unique molecular structure. It is characterized by its ethynyl linkage to a pyrimidin-5-carboxylate group and a 4,4-dimethyl-1-oxothiochroman-6-yl moiety. ethyl 2-((4,4-dimethyl-1-oxothiochroman-6-yl)ethynyl)pyrimidin-5-carboxylate has potential applications in various fields due to its distinct chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
Ethyl 2-((4,4-dimethyl-1-oxothiochroman-6-yl)ethynyl)pyrimidin-5-carboxylate is used as a key intermediate in the synthesis of retinoid compounds, which are known for their potential as anticancer agents. The compound's unique structure allows for the development of novel therapeutics that can target specific cancer-related pathways, making it a valuable asset in the fight against various types of cancer.
Used in Drug Delivery Systems:
In the field of drug delivery, ethyl 2-((4,4-dimethyl-1-oxothiochroman-6-yl)ethynyl)pyrimidin-5-carboxylate can be utilized as a component in the design of targeted drug delivery systems. Its chemical properties may enable the development of carriers that can selectively deliver therapeutic agents to cancer cells, thereby improving the efficacy and reducing the side effects of cancer treatments.
Used in Chemical Research:
As a complex organic molecule, ethyl 2-((4,4-dimethyl-1-oxothiochroman-6-yl)ethynyl)pyrimidin-5-carboxylate can also be employed in chemical research for the exploration of new reaction pathways and the synthesis of novel compounds with potential applications in various industries, including materials science, pharmaceuticals, and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 2131803-90-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,1,3,1,8,0 and 3 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2131803-90:
(9*2)+(8*1)+(7*3)+(6*1)+(5*8)+(4*0)+(3*3)+(2*9)+(1*0)=120
120 % 10 = 0
So 2131803-90-0 is a valid CAS Registry Number.
2131803-90-0Relevant articles and documents
Inhibition of cancer stem cell like cells by a synthetic retinoid
Chen, Junwei,Cao, Xin,An, Quanlin,Zhang, Yao,Li, Ke,Yao, Wenting,Shi, Fuchun,Pan, Yanfang,Jia, Qiong,Zhou, Wenwen,Yang, Fang,Wei, Fuxiang,Wang, Ning,Yu, Biao
, (2018)
Developing novel drugs that can abrogate the growth and metastasis of malignant tumors is a major challenge for cancer researchers. Here we describe a novel synthetic retinoid, namely WYC-209, which inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs), known to resist conventional drug treatment, with an IC50 of 0.19 μM in a dose-dependent manner. WYC-209 also inhibits proliferation of TRCs of human melanoma, lung cancer, ovarian cancer, and breast cancer in culture. Interestingly, the treated TRCs fail to resume growth even after the drug washout. Importantly, the molecule abrogates 87.5% of lung metastases of melanoma TRCs in immune-competent wild-type C57BL/6 mice at 0.22 mg kg-1 without showing apparent toxicity. Pretreating the melanoma TRCs with retinoic acid receptor (RAR) antagonists or with RAR siRNAs blocks or reduces the inhibitory effect of the molecule, suggesting that the target of the molecule is RAR. WYC-209 induces TRC apoptosis and pretreating the TRCs with caspase 3 inhibitor or depleting caspase 3 with siRNAs substantially rescues growth of TRCs from WYC-209 inhibition, suggesting that WYC-209 induces TRCs apoptosis primarily via the caspase 3 pathway. Our findings demonstrate the promise of the new retinoid WYC-209 in treating malignant melanoma tumors with high efficacy and little toxicity.
