213192-56-4

Usage

Uses

Used in Pharmaceutical Industry:
3-AMINO-3-(4-TRIFLUOROMETHOXY-PHENYL)-PROPIONIC ACID is used as a synthetic building block for the development of new drugs. Its unique structure allows for the creation of pharmaceuticals targeting various medical conditions, making it a valuable asset in drug discovery and design.
Used in Agrochemical Industry:
In the agrochemical sector, 3-AMINO-3-(4-TRIFLUOROMETHOXY-PHENYL)-PROPIONIC ACID is utilized as a precursor in the synthesis of agrochemicals. Its properties contribute to the development of effective compounds for agricultural applications, such as pesticides and herbicides, enhancing crop protection and yield.
Used in Organic Chemistry:
3-AMINO-3-(4-TRIFLUOROMETHOXY-PHENYL)-PROPIONIC ACID also serves as a fundamental building block in organic chemistry. It is employed in the synthesis of more complex molecules, facilitating advancements in chemical research and the creation of novel compounds with diverse applications.

Upstream product

• 141-82-2 malonic acid 
• 659-28-9 p-trifluoromethoxybenzaldehyde 

Downstream Products

• 288848-61-3 3-(4-trifluoromethoxyphenyl)-3-pyrrol-1-ylpropionic acid 
• 320727-89-7 3-[N-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-3-(4-trifluoromethoxy)-phenylpropionic acid 
• 288848-58-8 3-(4-trifluoromethoxyphenyl)-2,3-dihydro-1H-pyrrolizin-1-one 
• 288848-62-4 N-(3-(4-trifluoromethoxyphenyl)-3-pyrrol-1-ylpropionyl)pyrrolidine 
• 287959-34-6 methyl 3-amino-3-(4-trifluoromethoxyphenyl)propionate 

Relevant academic research and scientific papers

β-alanine derivatives

The invention relates to β-alanine derivatives of formula (I), wherein Q1, Q2, Q3, Q4, R1, R2, R3, R4, R5, R6and n have the meaning as disclosed

A one-pot synthesis of 3-amino-3-arylpropionic acids

3-Aminopropionic acids (β-amino acids) are biologically active compounds of interest in medicinal and pharmaceutical chemistry. Twenty-one 3-amino-3-arylpropionic acids were synthesized via a facile one-pot synthesis. In addition, a series of mechanistic studies have been performed to optimize the production of these β-amino acids. The reaction mechanism of this one-pot synthesis of β-amino acids, as well as the electronic effect of para-substitution and the influence of solvent polarity on the proposed reaction mechanism are discussed.

Solid-phase synthesis of a nonpeptide RGD mimetic library: New selective αvβ3 integrin antagonists

The solid-phase synthesis of a low molecular weight RGD mimetic library is described. Activities of the compounds in inhibiting the interaction of ligands, vitronectin and fibrinogen, with isolated immobilized integrins αvβ3 and αIIbβ3 were determined in a screening assay. Highly active and selective nonpeptide αvβ3 integrin antagonists with regard to orally bioavailability were developed, based on the aza-glycine containing lead compound 1. An important variation is the substitution of the aspartic amide of 1 by an aromatic residue. Furthermore, different guanidine mimetics have been incorporated to improve the pharmacokinetic profile. Exchange of the β-amino acid NH by a methylene moiety in one set of RGD mimetics leads to the azacarba analogue compounds representing a novel peptidomimetic approach, which should increase the metabolic stability.

New aromatase inhibitors. Synthesis and biological activity of aryl- substituted pyrrolizine and indolizine derivatives

We report herein the design and the synthesis of some aryl-substituted pyrrolizine and indolizine derivatives, on the basis of a hypothetical pharmacophore structure designed to fit the catalytic site of the human cytochrome P450 aromatase. The in vitro b