213267-16-4

Basic information

• Product Name: (S)-3-Hydroxy-3-methyl-4-phenyl-butyric acid
• Synonyms: (S)-3-Hydroxy-3-methyl-4-phenyl-butyric acid
• CAS NO: 213267-16-4
• Molecular Weight: 194.23
• Mol File: 213267-16-4.mol

Chemical Properties

• CAS DataBase Reference: (S)-3-Hydroxy-3-methyl-4-phenyl-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-Hydroxy-3-methyl-4-phenyl-butyric acid(213267-16-4)
• EPA Substance Registry System: (S)-3-Hydroxy-3-methyl-4-phenyl-butyric acid(213267-16-4)

Safety Data

• Hazardous Substances Data: 213267-16-4(Hazardous Substances Data)

Upstream product

• 90926-14-0 rac-2-methyl-3-phenyl-1,2-propanediol 
• 213267-15-3 (S)-3-Hydroxy-3-methyl-4-phenyl-butyronitrile 

Downstream Products

• 213267-17-5 (S)-(-)-3-Methyl-4-phenyl-1,3-butanediol 
• 213267-18-6 (S)-(-)-1,3-Diacetoxy-3-methyl-4-phenylbutane 

Relevant articles and documents

An efficient] large-scale synthesis of (R)-(-)-mevalonolactone using simple biological and chemical catalysts

Natural (R)-(-)-mevalonolactone (2) was synthesized in eight steps in 55% total yield and >99% ee employing an enantioconvergent chemoenzymatic route. In the key step, 2-benzyl-2-methyloxirane (±)-3 was deracemized on a large scale (10 g) using lyophilized cells of Nocardia EH1 and sulfuric acid. The product diol (S)-4 was isolated in 94% chemical yield and 94% optical purity.