21327-50-4Relevant articles and documents
Identification of novel scaffolds for potential anti- Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy- d -manno-octulosonate 8-phosphate synthase (Hp KDO8PS)
Cho, Sujin,Im, Hookang,Lee, Ki-Young,Chen, Jie,Kang, Hae Ju,Yoon, Hye-Jin,Min, Kyung Hoon,Lee, Kang Ro,Park, Hyun-Ju,Lee, Bong-Jin
, p. 188 - 202 (2016)
The crystal structure of 3-deoxy-d-manno-octulosonate-8-phosphate synthase (KDO8PS) from Helicobacter pylori (HpKDO8PS) was determined alone and within various complexes, revealing an extra helix (HE) that is absent in the structures of KDO8PS from other
Synthesis and pharmacological evaluation of a new class of 2-oxo-8- azaspiro (4,5)decan-1-ones as analogues of the muscarinic agonist RS-86
Cignarella,Villa,Barlocco
, p. 1439 - 1445 (2007/10/02)
A new series of 8-substituted-2-oxo-8-azapsiro (4,5)decan-1-ones has been synthesized and compounds tested for their cholinergic properties in comparison with the muscarinic agonist RS-86. Preliminary in vitro and in vivo pharmacological data indicate that none of them is provided with significant cholinergic effects either at central or peripheral level. A possible explanation for the lack of activity is given on the basis of conformational studies.