21331-43-1

Basic information

• Product Name: 2-AMINO-4-(2-NAPHTHYL)THIAZOLE
• Synonyms: IFLAB-BB F1386-0377;2-AMINO-4-(2-NAPHTHYL)THIAZOLE;4-(2-NAPHTHYL)-1,3-THIAZOL-2-AMINE;4-(2-NAPHTHYL)-1,3-THIAZOL-2-YLAMINE;4-(NAPHTHALEN-2-YL)THIAZOL-2-AMINE;4-NAPHTHALEN-2-YL-THIAZOL-2-YLAMINE;AKOS BBS-00000618;TIMTEC-BB SBB000670
• CAS NO: 21331-43-1
• Molecular Formula: C₁₃H₁₀N₂S
• Molecular Weight: 226.3
• Mol File: 21331-43-1.mol
• Article Data: 25

Chemical Properties

• Melting Point: 153-155°C
• Boiling Point: 443.9 °C at 760 mmHg
• Flash Point: 222.3 °C
• Appearance: /
• Density: 1.301 g/cm³
• Vapor Pressure: 4.46E-08mmHg at 25°C
• Refractive Index: 1.73
• PKA: 4.58±0.10(Predicted)
• BRN: 173533
• CAS DataBase Reference: 2-AMINO-4-(2-NAPHTHYL)THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-(2-NAPHTHYL)THIAZOLE(21331-43-1)
• EPA Substance Registry System: 2-AMINO-4-(2-NAPHTHYL)THIAZOLE(21331-43-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 21331-43-1(Hazardous Substances Data)

Usage

General Description

2-AMINO-4-(2-NAPHTHYL)THIAZOLE is a chemical compound with the molecular formula C11H9N3S. It is a thiazole derivative with a 2-aminophenyl and a 2-naphthyl group attached to the thiazole ring. It is commonly used in organic synthesis and pharmaceutical research due to its unique structure and potential pharmacological properties. The compound has been studied for its potential use in the development of drugs for various therapeutic applications, including antiviral, antibacterial, and antifungal agents. Its chemical structure and reactivity make it a valuable building block in the synthesis of more complex organic compounds.

InChI:InChI=1/C13H10N2S/c14-13-15-12(8-16-13)11-6-5-9-3-1-2-4-10(9)7-11/h1-8H,(H2,14,15)

Upstream product

• 2243-83-6 2-naphthaloyl chloride 
• 17356-08-0 thiourea 
• 93-08-3 methyl 2-naphthyl ketone 
• 55116-99-9 2-iodo-1-(2-naphthalenyl)ethanone 
• 613-54-7 2-Bromo-2'-acetonaphthone 
• 1147550-11-5 ammonium thiocyanate 

Downstream Products

• 7496-78-8 2-Acetylamino-4-ss-naphthyl-thiazol 
• 56503-93-6 3-(4-naphthalen-2-yl-thiazol-2-ylamino)-1-phenyl-propan-1-one 
• 77203-61-3 2,4-Dibromo-6-{[(E)-4-naphthalen-2-yl-thiazol-2-ylimino]-methyl}-phenol 
• 77203-47-5 2-{[(E)-4-Naphthalen-2-yl-thiazol-2-ylimino]-methyl}-phenol 
• 77203-54-4 4-Bromo-2-{[(E)-4-naphthalen-2-yl-thiazol-2-ylimino]-methyl}-phenol 
• 6664-60-4 4--2-<α-(N-methyl-anilino-acetamino)-thiazol 
• 6664-72-8 N-ethyl-N-phenyl-glycine 4-naphthalen-2-yl-thiazol-2-ylamide 
• 6121-99-9 N-benzyl-N-phenyl-glycine 4-naphthalen-2-yl-thiazol-2-ylamide 
• 313528-45-9 2-chloro-N-[4-(2-naphthyl)-1,3-thiazol-2-yl]-5-nitrobenzamide 
• 1180542-28-2 C₂₇H₂₂N₆O₇S₃ 
• 77203-99-7 2-[(3,5-Dibromo-2-hydroxy-phenyl)-(4-naphthalen-2-yl-thiazol-2-ylamino)-methyl]-cyclohexanone 
• 77203-94-2 2-[(5-Bromo-2-hydroxy-phenyl)-(4-naphthalen-2-yl-thiazol-2-ylamino)-methyl]-cyclohexanone 
• 77203-89-5 2-[(2-Hydroxy-phenyl)-(4-naphthalen-2-yl-thiazol-2-ylamino)-methyl]-cyclohexanone 
• 102060-64-0 6-(4-Chloro-phenyl)-5-[1-(4-dimethylamino-phenyl)-meth-(Z)-ylidene]-3-naphthalen-2-yl-5H-imidazo[2,1-b]thiazol-4-ylium; bromide 

Relevant articles and documents

Anticancer and antimicrobial activities of new thiazolyl-urea derivatives: gene expression, DNA damage, DNA fragmentation and SAR studies

The drug resistance became the major challenge in the antimicrobial and anticancer drugs therapy. Therefore, there is an urgent need to looking for new types of antimicrobial and anticancer agents. Herein we reported the synthesis and biological evaluatio

Solid state thiazole-based fluorophores: Promising materials for white organic light emitting devices

A facile and more efficient solvent-free mechanochemical synthetic route has been developed for the synthesis of a series of solid state white light emissive thiazole-based donor-acceptor (D-A) type fluorophores, 2-(3-pyridyl)/2-aminothiazoles from ω-bromomethylketones and pyridine-3-carbothioamide/thiourea in the presence of silica-supported HClO4 as a reusable solid Br?nsted acid catalyst at RT. The photophysical and electrochemical properties of these compounds have been derived. Most of the studied D-A type solid thiazole-based fluorophores emitted white light and it can be tuned from warm - ideal - cold white light by introduction of a variety of substituents at 4th position of 2-(3-pyridyl)/2-aminothiazoles. Further, HOMO and LUMO energy levels of the titled compounds are found to be in the range ?5.52 eV to ?5.72 eV and ?1.84 eV to ?2.45 eV, respectively. The lifetimes of these levels of thiazole-based fluorophores have been determined through luminescence decay curves and are found to be in the range of 7.7–11 μs. The photophysical and electrochemical properties of the synthesized thiazole-based fluorophores indicate that the compounds could be promising materials for white organic light emitting devices.

SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.