213328-48-4Relevant academic research and scientific papers
Total synthesis of uvaricin
Yazbak, Ahmad,Sinha, Subhash C.,Keinan, Ehud
, p. 5863 - 5868 (2007/10/03)
The first total synthesis of naturally occurring (+)-uvaricin was achieved using three consecutive Sharpless asymmetric dihydroxylation (AD) reactions to place the necessary oxygen functions on a 'naked' carbon skeleton in a regio- and enantioselectively controlled manner. The appropriate bis-THF ring system was constructed using a Williamson type etherification reaction on a functionalized bis-mesylate intermediate.
