21333-02-8Relevant articles and documents
UV365 light promoted catalyst-free synthesis of pyrimido[4,5-b] quinoline-2,4-diones in aqueous-glycerol medium
Nongthombam, Geetmani Singh,Kharmawlong, George Kupar,Kumar, John Elisa,Nongkhlaw, Rishanlang
supporting information, p. 9436 - 9442 (2018/06/18)
Herein, a highly efficient and environmentally benign protocol for the synthesis of biologically important pyrimido[4,5-b]quinolinone-2,4-diones from aromatic amines, barbituric acid and aryl aldehyde is reported. This process takes place at room temperat
Synthesis, biological active molecular design, and molecular docking study of novel deazaflavin-cholestane hybrid compounds
Shrestha, Ajaya R.,Shindo, Takashi,Ashida, Noriyuki,Nagamatsu, Tomohisa
body text, p. 8685 - 8696 (2009/04/11)
Novel deazaflavin-cholestane hybrid compounds, 3′,8′-disubstituted-5′-deazacholest-2,4-dieno[2,3-g]pteridine-2′,4′(3′H,8′H)-diones, have been synthesized by condensation reaction between 6-(monosubstituted amino)-pyrimidin-2,4(1H,3H)-diones and 2-hydroxymethylenecholest-4-en-3-one in presence of p-toluenesulfonic acid monohydrate and diphenyl ether. The antitumor activities against human tumor cell lines (CCRF-HSB-2 and KB cells) have been investigated in vitro, and many of these compounds showed promising antitumor activities. Furthermore, molecular docking study using LigandFit within the software package Discovery Studio 1.7 was done for lead optimization of these compounds as potential PTK inhibitors. In general, all of the synthesized steroid-hybrid compounds showed good binding affinities into PTK (PDB code: 1t46).
Flavins as Potential Antimalarials. 1. 10-(Halophenyl)-3-methylflavins
Cowden, William B.,Clark, Ian A.,Hunt, Nicholas H.
, p. 799 - 801 (2007/10/02)
A series of 10-(halomethyl)-3-methylflavins was prepared by the condensation of 6-(haloanilino)-3-methyluracils with nitrosobenzene.A number of these flavins effectively cured lethal Plasmodium vinckei malarial infections in mice when administered by eith
