213331-79-4Relevant academic research and scientific papers
Exploration of modalities in building α-O-linked systems through glycal assembly: A total synthesis of the mucin-related F1α antigen
Chen, Xiao-Tao,Sames, Dalibor,Danishefsky, Samuel J.
, p. 7760 - 7769 (2007/10/03)
The total synthesis of the F1α antigen, a member of the tumor- associated O-linked mucin glycopeptides, was achieved via two alternative routes. In the first approach, an α-O-linkage between serine/threonine and Ga1NAc (2-deoxy-2-N-acetylamino-D-galactose
Synthetic and immunological studies on clustered modes of mucin-related Tn and TF O-linked antigens: The preparation of a glycopeptide-based vaccine for clinical trials against prostate cancer
Kuduk, Scott D.,Schwarz, Jacob B.,Chen, Xiao-Tao,Glunz, Peter W.,Sames, Dalibor,Ragupathi, Govindaswami,Livingston, Philip O.,Danishefsky, Samuel J.
, p. 12474 - 12485 (2007/10/03)
The syntheses of two tumor-associated carbohydrate antigens, Tn and TF, have been achieved using glycal assembly and cassette methodologies. These synthetic antigens were subsequently clustered (c) and immunoconjugated to a carrier protein (KLH or BSA) or
