213402-56-3

Upstream product

• 213402-38-1 ethyl 2-(5-benzoyl-3-nitro-2-thienylthio)acetate 
• 213402-42-7 6-benzoyl-1H-thieno[2,3-b][1,4]thiazin-2(3H)-one 
• 95729-24-1 (5-Chlor-4-nitro-2-thienyl)-phenylmethanon 
• 213402-49-4 6-benzyl-2,3-dihydro-1H-thieno[2,3-b][1,4]thiazine-2-one 

Downstream Products

• 852993-94-3 (4-aminophenyl)(6-benzyl-2,3-dihydro-1H-thieno[2,3-b][1,4]thiazin-1-yl)methanone 
• 213402-63-2 6-benzyl-2,3-dihydro-1H-thieno[2,3-b][1,4]thiazine-1-carboxylic acid 4-nitrophenyl ester 

Relevant academic research and scientific papers

Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. Part 19([1]): Thieno[2,3-b][1,4]thiazines with calcium antagonistic and potassium opening activities

In this study novel substituted 6-benzyl-thieno[2,3-b][1,4]thiazines with an urea moiety were synthesized. Structural modifications of the amino side chain were carried out with the aim of finding tissue specific compounds. The effects on papillary muscles, right atria, aortic strips, and terminal ilea were investigated. Compounds 10c and 10d showed the most potent negative inotropic effect. The calcium antagonism of all derivatives occurred in a non-competitive manner, which may indicate that they also have potassium channel opening activities.