213411-13-3

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 213411-07-5 ((E)-7-Azido-hept-3-en-1-ynyl)-trimethyl-silane 
• 118495-97-9 (E)-7-Trimethylsilanyl-hept-4-en-6-yn-1-ol 

Downstream Products

• 213411-15-5 N-((E)-Hept-4-en-6-ynyl)-4-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

Stereoselective Total Synthesis of (±)-Swainsonine Based on Endo Mode Cyclization

A new stereoselective total synthesis of (±)-swainsonine is described. Successive treatment of cis-3,4-epoxy-7-(p-toluenesulfonamido)-1-heptyne with dicobalt octacarbonyl, Lewis acid, and cerium-(IV) ammonium nitrate effected stereoselective formation of the trans-2-ethynyl-3-hydroxypiperidine skeleton with retention of configuration at the propynyl center. The piperidine derivative thus prepared was converted into the title compound efficiently.