21344-52-5Relevant academic research and scientific papers
Direct C-H Cyanoalkylation of Quinoxalin-2(1H)-ones via Radical C-C Bond Cleavage
Yang, Lin,Gao, Pin,Duan, Xin-Hua,Gu, Yu-Rui,Guo, Li-Na
, p. 1034 - 1037 (2018)
An efficient synthesis of cyanoalkylated heteroarenes via iron-catalyzed direct C-H cyanoalkylation of heteroarenes has been developed. Structurally diverse cyanoalkyl motifs generated through C-C bond cleavage of cyclobutanone oxime esters have been intr
Metal-Free Direct C-H Cyanoalkylation of Quinoxalin-2(1 H)-Ones by Organic Photoredox Catalysis
Zhang, Wei,Pan, Yu-Liang,Yang, Chen,Chen, Li,Li, Xin,Cheng, Jin-Pei
, p. 7786 - 7795 (2019)
Green and efficient C-C bond cleavage/cyanoalkylation of quinoxalin-2(1H)-ones and other heteroarenes under visible light or sunlight irradiation is described. The reaction proceeds under mild conditions at room temperature without transition-metal catalysts and extra bases. Notably, the products enable facile transformations to various significant organic compounds.
Minisci-Type C–H Cyanoalkylation of Heteroarenes Through N–O/C–C Bonds Cleavage
Jian, Yong,Chen, Ming,Yang, Chao,Xia, Wu-jiong
supporting information, p. 1439 - 1442 (2019/05/16)
A visible-light-induced C–H cyanoalkylation of heteroarenes was described, in which cycloketone oximes were readily transformed into carbon-centered radicals with a terminal cyano-group via N–O/C–C bonds cleavage in one phtochemical step. This reaction protocol displayed a broad substrate scope of heterocycle compounds, and it provided a promising strategy for the installation of cyanoalkyl groups onto heteroarenes.
Functionalized orthoesters as powerful building blocks for the efficient preparation of heteroaromatic bicycles
Bastug, Gulluzar,Eviolitte, Christophe,Markó, István E.
supporting information; experimental part, p. 3502 - 3505 (2012/08/08)
By combining substituted anilines with functionalized orthoesters, an efficient and connective methodology for the preparation of benzoxazole, benzothiazole, and benzimidazole derivatives has been established. The versatility of this approach enables the development of new libraries of heterocycles containing multifunctional sites.
