21344-90-1

Basic information

• Product Name: 4-(2-CHLORO-PHENYL)-THIAZOL-2-YLAMINE
• Synonyms: ART-CHEM-BB B000318;AURORA 22577;BUTTPARK 41\03-43;4-(2-CHLOROPHENYL)-1,3-THIAZOL-2-AMINE;4-(2-CHLORO-PHENYL)-THIAZOL-2-YLAMINE;AKOS BBS-00007981;AKOS B000318;2-Amino-4-(2-chlorophenyl)-1,3-thiazole
• CAS NO: 21344-90-1
• Molecular Formula: C₉H₇ClN₂S
• Molecular Weight: 210.68
• Mol File: 21344-90-1.mol
• Article Data: 17

Chemical Properties

• Melting Point: 132-138°C
• Boiling Point: 371.1°Cat760mmHg
• Flash Point: 178.3°C
• Appearance: /
• Density: 1.389g/cm³
• Vapor Pressure: 1.05E-05mmHg at 25°C
• Refractive Index: 1.667
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 4-(2-CHLORO-PHENYL)-THIAZOL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-CHLORO-PHENYL)-THIAZOL-2-YLAMINE(21344-90-1)
• EPA Substance Registry System: 4-(2-CHLORO-PHENYL)-THIAZOL-2-YLAMINE(21344-90-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 21344-90-1(Hazardous Substances Data)

Usage

General Description

4-(2-chloro-phenyl)-thiazol-2-ylamine is a chemical compound with the molecular formula C9H7ClN2S. It belongs to the thiazole class of compounds and contains a thiazole ring with a chlorine-substituted phenyl group attached. This chemical is commonly used as a building block in organic synthesis and can be found in various pharmaceuticals and agrochemicals. It has been studied for its potential antibacterial, antifungal, and antiviral properties, making it an important candidate for the development of new drugs. Additionally, it is also used as a precursor in the synthesis of other important compounds, making it a valuable and versatile chemical in the field of organic chemistry.

InChI:InChI=1/C9H7ClN2S/c10-7-4-2-1-3-6(7)8-5-13-9(11)12-8/h1-5H,(H2,11,12)

Upstream product

• 3900-89-8 2-Chlorobenzeneboronic acid 
• 609-65-4 o-chlorobenzoyl chloride 
• 17356-08-0 thiourea 
• 5000-66-8 2-chlorophenacyl bromide 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 673477-11-7 4-(2-chlorophenyl)thiazol-2-amine hydrobromide 

Downstream Products

• 528583-96-2 2-amino-4-(2-chlorophenyl)-5-(4-tolylazo)thiazole 
• 376349-72-3 4,5-Dichloro-N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-2-thiophenesulfonamide 
• 376349-32-5 N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-4-propylbenzenesulfonamide 
• 376349-67-6 2,3,4-Trichloro-N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]benzenesulfonamide 
• 376349-38-1 3-Chloro-N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide 
• 376349-44-9 2,4,6-Trichloro-N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]benzenesulfonamide 
• 376349-63-2 2,4-Dichloro-N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-6-methylbenzenesulfonamide 
• 376349-77-8 3-Bromo-5-chloro-N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-2-thiophenesulfonamide 
• 1229380-22-6 (R)-tert-butyl 3-benzyl-4-(4-(2-chlorophenyl)thiazol-2-ylamino)-4-oxobutanoate 
• 904771-57-9 4-((4-(2-chlorophenyl)thiazol-2-yl)amino)-4-oxobutanoic acid 

Relevant articles and documents

A 4-(o-chlorophenyl)-2-aminothiazole: Microwave assisted synthesis, spectral, thermal, XRD and biological studies

A 4-(o-chlorophenyl)-2-aminothiazole (CPAT) has been synthesized by reacting o-chloroacetophenone, iodine and thiourea under microwave irradiation as a green chemistry approach. The reactions proceed selectively and within a couple of minutes giving high

Synthesis of 2-aminothiazoles via rhodium-catalyzed carbenoid insertion/annulation of sulfoxonium ylides with thioureas

Sulfoxonium ylides as carbene precursors couple smoothly with thioureas in the presence of 5 mol% of rhodium(II) acetate dimmer via carbenoid insertion to afford the corresponding 2-aminothiazoles with high chemoselectivity, providing a facile and efficient approach to access a variety of 2-aminothiazole derivatives with good functional groups tolerance.

Method for preparing 2-aminothiazole compound

The invention discloses a method for preparing a 2-aminothiazole compound. The method comprises the following steps: in an organic solvent, carrying out a condensation reaction on thiourea representedby a formula (II) and a ketone compound represented by a formula (III) at 50-120 DEG C for 6-24 h under the catalysis of elemental iodine, and after the reaction is finished, carrying out post-treatment on the reaction solution to obtain the 2-aminothiazole compound represented by a formula (I). According to the invention, the method has characteristics of cheap and easily available reaction rawmaterials, mild reaction conditions, simpleness, no requirement of transition metal catalysts and a stoichiometric halogenating reagents and cost reducing, and can be used for synthesizing a series of2-aminothiazole derivatives, and the prepared products can be used as important intermediates for synthesizing thiazole structure-containing drugs or bioactive compounds.