213454-17-2

Upstream product

• 144001-86-5 Methyl 2-(dimethoxyphosphinyl)-2-ethanoate 
• 250735-65-0 (S)-2-((1R,2S)-2-Acetoxy-3-oxo-1-phenylacetoxy-propyl)-aziridine-1-carboxylic acid benzyl ester 
• 213454-14-9 Phenyl-acetic acid (E)-(1R,2R)-1-((S)-1-benzyloxycarbonylamino-2-methanesulfonyloxy-ethyl)-2-(tert-butyl-dimethyl-silanyloxy)-pent-3-enyl ester 
• 213454-15-0 Phenyl-acetic acid (E)-(1R,2R)-2-acetoxy-1-((S)-1-benzyloxycarbonylamino-2-methanesulfonyloxy-ethyl)-pent-3-enyl ester 
• 1054650-04-2 Phenyl-acetic acid (E)-(1R,2R)-1-((S)-1-benzyloxycarbonylamino-2-methanesulfonyloxy-ethyl)-2-hydroxy-pent-3-enyl ester 
• 213454-13-8 Methanesulfonic acid (E)-(2S,3R,4R)-2-benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-hept-5-enyl ester 
• 213454-16-1 (S)-2-((E)-(1R,2R)-2-Acetoxy-1-phenylacetoxy-pent-3-enyl)-aziridine-1-carboxylic acid benzyl ester 
• 213454-11-6 (S)-4-[(E)-(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-hydroxy-pent-3-enyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 213454-12-7 [(E)-(1S,2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-1-hydroxymethyl-hex-4-enyl]-carbamic acid benzyl ester 
• 117833-92-8 (4S)-3-benzyloxycarbonyl-2,2-dimethyloxazolidine-4-carbaldehyde 

Downstream Products

• 213454-18-3 methyl (2E,4S,5R)-4-acetoxy-5-[(2S)-N-(benzyloxycarbonyl)aziridin-2-yl]-3-bromo-5-phenylacetoxy-2-[N-methoxycarbonylamino]-2-pentenoate 
• 213454-22-9 methyl (2Z,4S,5R)-4-acetoxy-5-[(2S)-N-(benzyloxycarbonyl)aziridin-2-yl]-3-bromo-5-phenylacetoxy-2-[N-methoxycarbonylamino]-2-pentenoate 
• 213454-19-4 (E)-(4S,5R)-4-Acetoxy-5-(S)-aziridin-2-yl-3-bromo-2-methoxycarbonylamino-5-phenylacetoxy-pent-2-enoic acid methyl ester 
• 213454-20-7 methyl (2E,3R,4R,5S)-3-acetoxy-α-methoxycarbonylamino-4-phenylacetoxy-1-azabicyclo[3.1.0]-hexene-Δ^2α-acetate 

Relevant academic research and scientific papers

Synthesis of naturally occurring antitumor agents: Stereocontrolled synthesis of the azabicyclic ring system of the azinomycins

Full details of the synthesis of the fully elaborated aziridino[1,2-a]pyrrolidine substructure 2 of the antitumor agents azinomycins A and B are reported. Stereoselective bromination of dehydroamino acid 4 provided control of olefin configuration in the f