213459-58-6Relevant academic research and scientific papers
Modifications of the α,β-double bond in chalcones only marginally affect the antiprotozoal activities
Nielsen, Simon Feldbaek,Kharazmi, Arsalan,Christensen, S. Brogger
, p. 937 - 945 (2007/10/03)
Methods for selective alkylation of chalcones in the α- or β-position and for selective reduction of the α,β-double bond have been developed. The antiparasitic potencies of the α,β-double bond modified chalcones only differ marginally from the potencies of the parent chalcones indicating that the propenone residue only functions as a spacer between the two benzene rings, which are the true pharmacophore. Copyright (C) 1998 Elsevier Science Ltd.
