213464-00-7

Upstream product

• 64485-90-1 2-(2-aminothiazol-4-yl)-2-(methoxy)iminoacetic acid 
• 131065-42-4 (6R,7R)-3-Hydroxy-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 213463-97-9 (6R,7R)-7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-trifluoromethanesulfonyloxy-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 76609-91-1 2-(2-tritylamino-4-thiazolyl)-2-methoxyiminoacetyl chloride 

Relevant academic research and scientific papers

Novel cephalosporin derivatives possessing a bicyclic heterocycle at the 3-Position. Part I: Synthesis and biological activities of 3-(benzothiazol-2-yl)thiocephalosporin derivatives, CP0467 and related compounds

A series of cephalosporin derivatives with various bicyclic heterocycles at the C-3 position was synthesized and evaluated for antibacterial activity. Among them CP0467 (3a) showed excellent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) (MIC90=6.25μg/mL), and extremely high affinity for the penicillin binding protein 2' of MRSA (I50=0.49μg/mL). Furthermore, 3a showed a long-acting pharmacokinetic profile in mice (AUC(∞)=482.3μg/h/mL and T(1/2)=1.9h). Copyright (C) 1998 Elsevier Science Ltd.