213466-25-2

Upstream product

• 43201-07-6 (R)-2-hydroxyhexanoic acid 
• 327-56-0 D-norleucine 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 152830-08-5 (2R)-2-hydroxyhexanoic acid benzyl ester 

Downstream Products

• 442521-58-6 2-({2-[3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propyl]-4,5-dipentyl-phenyl}-methyl-amino)-hexanoic acid benzyl ester 
• 442525-53-3 2-({2-[3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propyl]-5-octyl-phenyl}-methyl-amino)-hexanoic acid benzyl ester 
• 442521-65-5 (S)-2-{[2-(2,3-Dihydroxy-propyl)-5-octyl-phenyl]-methyl-amino}-hexanoic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis, conformation and PKC isozyme surrogate binding of new lactone analogues of benzolactam-V8s

To investigate the role of the amide hydrogen of benzolactam-V8s (1-3) on protein kinase C (PKC) isozyme binding, new lactone analogues of benzolactam-V8s with hydrophobic side chains at positions 8 and/or 9 (5-8) were synthesized. The PKC binding affinities of 8- and 9-decylbenzolactone-V8 (5,6) were much lower than those of 8- and 9-decylbenzolactam-V8 (2,3), respectively, indicating that the amide hydrogen of benzolactam-V8s plays a critical role in PKC binding. 8-Decylbenzolactam-V8 (2) showed lower binding affinities to all PKC isozymes compared with those of 9-decylbenzolactam-V8 (3). The binding affinities of 8-substituted benzolactones (5,7,8) were also lower than those of 9-decylbenzolactone-V8 (6), but their PKC isozyme selectivity was higher than those of 2, 3 and 6. 8-Decybenzolactone-V8 (5) exhibited the most significant η-C1B selectivity among the four benzolactones (5-8) synthesized in this study.