213470-31-6Relevant articles and documents
BENZOXAZINONE DERIVATIVES, PREPARATION THEREOF AND USES IN THE TREATMENT OF CNS AND OTHER DISORDERS
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Page 42, (2008/06/13)
Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed:wherein A, R1, R2, R3, p, q, A and X are as defined in the specification. Preparation of the compounds and uses in the treatment of CNS and other disorders, including dep
Friedlaender Synthesis of Substituted Quinolines from N-Pivaloylanilines
Ubeda, J. Ignacio,Villacampa, Mercedes,Avendano, Carmen
, p. 1176 - 1180 (2007/10/03)
Synthesis of a great variety of quinoline derivatives has been developed by lithiation of N-pivaloylanilines with sec-BuLi, formylation with DMF, and subsequent condensation with active methylene groups of aldehydes or ketones (KHMDS).The pivaloyloxy group is eliminated during one-pot procedure in most cases.The scope of the reaction has been studied, showing that the method is limited by the nature of intermediate compounds. - Keywords: Friedlaender synthesis; pivaloylanilines; quinolines; o-metalation; one-pot synthesis