213487-23-1

Upstream product

• 807370-67-8 1-{(2R,3R,4S,5R)-3-Azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-trimethylsilanyloxy-tetrahydro-furan-2-yl}-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one 
• 173170-12-2 2,2'-O-anhydro-1-<5'-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl>uracil 
• 807370-61-2 2'-azido-5'-O-(4,4'-dimethoxytrityl)-3'-O-trimethylsilyl-2'-deoxyuridine 
• 26929-65-7 2'-azido-2'-deoxyuridine 
• 177980-10-8 2'-azido-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 177980-09-5 3'-O-acetyl-2'-azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine 

Downstream Products

• 213487-25-3 Carbonic acid (2R,3S,4R,5R)-4-azido-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-(4-nitro-phenyl)-ethyl ester 
• 174221-87-5 2'-amino-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine 
• 213487-27-5 (1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester 
• 807370-92-9 N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamino-2'-deoxycytidine 
• 807370-85-0 5'-O-(4,4'-dimethoxytrityl)-2'-methoxyoxalylamino-2'-deoxycytidine 

Relevant academic research and scientific papers

Monomers for oligonucleotide synthesis with linkers carrying reactive residues: II. The synthesis of phosphoamidites on the basis of uridine and cytosine and containing a linker with methoxyoxalamide groups in position 2′

A convenient preparative synthesis of 2′-amino-2′-deoxyuridine was developed. Starting from 2′-amino-2′-deoxyuridine and 2′-amino-2′-deoxycytidine, monomers for the phosphoamidite oligonucleotide synthesis were obtained that carry a linker with methoxyoxalamide groups in position 2′.

Synthesis of Phosphoramidite Building Blocks of 2′-Amino-2′-deoxyribonucleosides: New Compounds for Oligonucleotide Synthesis

The chemical synthesis of 2′-amino-2′-deoxyribonucleosides of uracil, cytosine, adenine, and guanine, and their conversion into suitably protected 3′-phosphoramidite building blocks 35-40 for oligonucleotide synthesis are described. The aglycone and the 2′-amino functions were protected using the 2-(4-nitrophenyl)ethoxycarbonyl (npeoc) group. The synthesis of the 3′-?-succinyl (3′-?-(3-carboxypropanoyl))-substituted starting nucleoside 41 is described and its behavior examined in solution and on solid phase with regard to an anticipated migration during 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) deprotection. Oligonucleotides were prepared using the new building blocks, and their hybridization properties were studied by UV-melting techniques.