213487-24-2

Upstream product

• 88091-70-7 1-methyl-3-[2-(4-nitrophenyl)ethoxycarbonyl]imidazolium chloride 
• 213487-22-0 2'-azido-2'-deoxy-5'-O-(4-methoxytrityl)cytidine 
• 213487-20-8 3'-O-acetyl-2'-azido-2'-deoxy-5'-O-(4-methoxytrityl)uridine 
• 213487-19-5 2'-azido-2'-deoxy-5'-O-(4-methoxytrityl)uridine 
• 38642-30-7 2,2'-anhydro-1-[5-O-(4-methoxytrityl)-β-D-arabinofuranosyl]uracil 

Downstream Products

• 213487-26-4 (1-{(2R,3R,4S,5R)-4-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester 

Relevant academic research and scientific papers

Synthesis of Phosphoramidite Building Blocks of 2′-Amino-2′-deoxyribonucleosides: New Compounds for Oligonucleotide Synthesis

The chemical synthesis of 2′-amino-2′-deoxyribonucleosides of uracil, cytosine, adenine, and guanine, and their conversion into suitably protected 3′-phosphoramidite building blocks 35-40 for oligonucleotide synthesis are described. The aglycone and the 2′-amino functions were protected using the 2-(4-nitrophenyl)ethoxycarbonyl (npeoc) group. The synthesis of the 3′-?-succinyl (3′-?-(3-carboxypropanoyl))-substituted starting nucleoside 41 is described and its behavior examined in solution and on solid phase with regard to an anticipated migration during 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) deprotection. Oligonucleotides were prepared using the new building blocks, and their hybridization properties were studied by UV-melting techniques.