21352-21-6

Basic information

• Product Name: N-(pyrazin-2-yl)acetamide
• Synonyms: acetamide, N-2-pyrazinyl-; N-(Pyrazin-2-yl)acetamide
• CAS NO: 21352-21-6
• Molecular Formula: C₆H₇N₃O
• Molecular Weight: 137.1393
• Mol File: 21352-21-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 344.4°C at 760 mmHg
• Flash Point: 162.1°C
• Density: 1.258g/cm³
• Vapor Pressure: 6.61E-05mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: N-(pyrazin-2-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(pyrazin-2-yl)acetamide(21352-21-6)
• EPA Substance Registry System: N-(pyrazin-2-yl)acetamide(21352-21-6)

Safety Data

• Hazardous Substances Data: 21352-21-6(Hazardous Substances Data)

Usage

General Description

N-(pyrazin-2-yl)acetamide is a chemical compound with the molecular formula C7H8N4O. It is a derivative of pyrazine and acetamide, and is used in the synthesis of various pharmaceutical and agrochemical products. The compound exhibits a wide range of biological activities, including antiviral, antibacterial, and antifungal properties. It has also been studied for its potential use in the treatment of various diseases, including cancer and neurological disorders. N-(pyrazin-2-yl)acetamide is a versatile building block in organic synthesis and has potential applications in various fields, including medicinal chemistry and agricultural science.

Upstream product

• 124-42-5 acetamidine hydrochloride 
• 4949-13-7 2-fluoropyrazine 
• 5049-61-6 2-Aminopyrazine 
• 108-24-7 acetic anhydride 

Downstream Products

• 20914-69-6 2-Methyl-s-triazolo<1,5-a>pyrazine 
• 1029560-82-4 C₆H₉N₄O⁽¹⁺⁾*C₉H₁₁O₃S^(1-) 

Relevant articles and documents

Access to 2-pyridinylamide and imidazopyridine from 2-fluoropyridine and amidine hydrochloride

Under catalyst-free conditions, an efficient method to synthesize 2-pyridinylamides has been developed, and the protocol uses inexpensive and readily available 2-fluoropyridine and amidine derivatives as the starting materials. Simultaneously, the copper-catalysed approach to imidazopyridine derivatives has been established with high chemoselectivity and regiospecificity. The results suggest that the nitrogen-heterocycles containing iodide substituents can also be compatible for the reaction via the cascade Ullmann-type coupling, and the nucleophilic substitution reaction provides the target products in a one-pot manner.

Quinoline derivatives as neurokinin receptor antagonists

The present invention relates to substituted quinoline hydrazides of Formula (I): wherein R1, R2, R3, R4, R5, X, Y and Z are defined herein, pharmaceutical compositions comprising them and their use in treating diseases mediated by neurokinin-2 and/or neurokinin-3 (NK-3) receptors. These compounds can thus be used in methods of treatment to suppress and treat such disorders.