213539-48-1

Basic information

• Product Name: N,N',N''-trimethyl-N,N',N''-tris(2-pyridylmethyl)-cis,cis-1,3,5-triaminocyclohexane
• Synonyms: N,N',N''-trimethyl-N,N',N''-tris(2-pyridylmethyl)-cis,cis-1,3,5-triaminocyclohexane
• CAS NO: 213539-48-1
• Molecular Weight: 444.623
• Mol File: 213539-48-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,N',N''-trimethyl-N,N',N''-tris(2-pyridylmethyl)-cis,cis-1,3,5-triaminocyclohexane(CAS DataBase Reference)
• NIST Chemistry Reference: N,N',N''-trimethyl-N,N',N''-tris(2-pyridylmethyl)-cis,cis-1,3,5-triaminocyclohexane(213539-48-1)
• EPA Substance Registry System: N,N',N''-trimethyl-N,N',N''-tris(2-pyridylmethyl)-cis,cis-1,3,5-triaminocyclohexane(213539-48-1)

Safety Data

• Hazardous Substances Data: 213539-48-1(Hazardous Substances Data)

Upstream product

• 4377-33-7 2-chloromethylpyridine 
• 50636-12-9 N,N',N''-trimethyl-1,3,5-cis,cis-triaminocyclohexane 

Relevant articles and documents

Evaluation of copper chelation agents as anti-angiogenic therapy

The design, synthesis and evaluation of N,N′,N″-tris(2-pyridylmethyl)-cis,cis-1,3,5,-triaminocyclohexane (tachpyr, 1) derivatives as novel anti-angiogenic agents were performed in an in vitro endothelial cell proliferation assay to assess their cytotoxicity and selectivity. The selective nature of the anti-angiogenic agents for human umbilical vein endothelial cells (Huvec) was compared to a normal fibroblast cell line and a human Glioma cell line to evaluate these compounds. N,N′,N″-tris(2-mercaptoethyl)-cis,cis-1,3,5-triaminocyclohexane trihydrochloride (3b) was superior to tachpyr in terms of selectivity of its inhibitory activity toward the proliferation of Huvec compared to the fibroblast and human Glioma cell lines.