21354-01-8

Basic information

• Product Name: N-(2-nitrosophenyl)acetamide
• Synonyms: N-(2-nitrosophenyl)acetamide
• CAS NO: 21354-01-8
• Molecular Formula: C₈H₈N₂O₂
• Molecular Weight: 164.16132
• EINECS: 244-345-7
• Mol File: 21354-01-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 105-110 °C
• Boiling Point: 376.2°Cat760mmHg
• Flash Point: 181.3°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 7.38E-06mmHg at 25°C
• Refractive Index: 1.568
• PKA: 14.24±0.70(Predicted)
• CAS DataBase Reference: N-(2-nitrosophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-nitrosophenyl)acetamide(21354-01-8)
• EPA Substance Registry System: N-(2-nitrosophenyl)acetamide(21354-01-8)

Safety Data

• Hazardous Substances Data: 21354-01-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H8N2O2/c1-6(11)9-7-4-2-3-5-8(7)10-12/h2-5H,1H3,(H,9,11)

Upstream product

• 552-32-9 o-nitroacetanilide 
• 95-54-5 1,2-diamino-benzene 
• 34801-09-7 N-(2-aminophenyl)acetamide 
• 88-74-4 2-nitro-aniline 
• 108-24-7 acetic anhydride 

Downstream Products

• 117883-88-2 4-benzotriazol-2-yl-benzenesulfonic acid ; sodium-salt 
• 1237-71-4 bis-(2-acetylamino-phenyl)-diazene-N-oxide 
• 62189-02-0 2-acetamido-2''-amino-ortho-bisazobenzene 
• 13666-95-0 2,2'-diacetamido-ortho-azobenzene 
• 1346157-77-4 2-amino-2'-acetamido-tris-ortho-azobenzene 
• 1202564-22-4 2-acetamido-2-amino-ortho-bisazobenzene 
• 1346157-84-3 2-amino-ortho-bisazobenzene 
• 1346157-86-5 2-amino-2-nitro-ortho-bisazobenzene 
• 1346157-88-7 2-acetamido-2-nitro-ortho-bisazobenzene 
• 1346157-89-8 2-acetamido-ortho-bisazobenzene 
• 1346157-91-2 2-amino-tris-ortho-azobenzene 
• 1346157-92-3 2-nitro-tris-ortho-azobenzene 
• 1346157-95-6 2-acetamido-2'-nitro-tris-ortho-azobenzene 
• 1346157-78-5 2,2-dinitro-tetra-ortho-azobenzene 

Relevant articles and documents

Azobenzene-diamides as Photopharmacological Ligands for Insect Ryanodine Receptor

Photoresponsive ligands are powerful tool compounds for studying receptor function with spatiotemporal resolution. However, to the best of our knowledge, such a ligand is not available for the ryanodine receptor (RyR). Herein, we present a photochromic ligand (PCL) for insect RyR by decorating chlorantraniliprole (CHL) with photoswitchable azobenzene (AB). We demonstrated that one potent ligand, named ABCHL13, shows light-induced reversible trans-cis isomerization and 3.5-fold insecticidal activity decrease toward oriental armyworm (Mythimna separata) after UV-light irradiation, that is, trans-ABCH13 has higher activity than the cis-ABCH13. ABCHL13 enables optical control over intracellular Ca2+ release in dorsal unpaired median (DUM) neurons of M. separata and American cockroach (Periplaneta americana) and cardiac function of P. americana. Our results provide a first photopharmacological toolkit that is applicable to light-dependent regulation of RyR and heart beating.

Synthesis and photochemical properties of oligo-ortho-azobenzenes

Azobenzenes have attracted great interest in recent years because of their ability to change conformation upon irradiation. This property has been featured in several applications not only in organic chemistry but also in biology. Even though monoazobenzenes have been extensively studied and documented in the literature, only a few methods are available for the synthesis of oligo-ortho-azobenzenes. Also, their photochemical properties have not been reported so far. This study shows an efficient strategy for the preparation of oligo-ortho-azobenzenes and the investigation of their photochemical properties. It is demonstrated that the absorption spectra are highly influenced by the substituents. Interestingly, none of the ortho-bis-, tris-, or tetra-azobenzenes showed any E → Z isomerization. Only the ortho-nitrogen-substituted monoazobenzenes' photochromic behavior upon UV irradiation was observed.