21354-23-4

Basic information

• Product Name: 4-BROMO-N-(4-CHLOROPHENYL) BENZAMIDE
• Synonyms: 4-BROMO-N-(4-CHLOROPHENYL) BENZAMIDE
• CAS NO: 21354-23-4
• Molecular Formula: C₁₃H₉BrClNO
• Molecular Weight: 310.57366
• Mol File: 21354-23-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 217-217.5 °C
• Boiling Point: 332°Cat760mmHg
• Flash Point: 154.6°C
• Appearance: /
• Density: 1.58g/cm³
• Vapor Pressure: 0.00015mmHg at 25°C
• Refractive Index: 1.67
• PKA: 12.27±0.70(Predicted)
• CAS DataBase Reference: 4-BROMO-N-(4-CHLOROPHENYL) BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-N-(4-CHLOROPHENYL) BENZAMIDE(21354-23-4)
• EPA Substance Registry System: 4-BROMO-N-(4-CHLOROPHENYL) BENZAMIDE(21354-23-4)

Safety Data

• Hazardous Substances Data: 21354-23-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H9BrClNO/c14-10-3-1-9(2-4-10)13(17)16-12-7-5-11(15)6-8-12/h1-8H,(H,16,17)

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 106-47-8 4-chloro-aniline 
• 586-76-5 4-Bromobenzoic acid 
• 586-75-4 4-chlorobenzoyl chloride 

Downstream Products

• 954146-56-6 C₂₃H₁₃BrClN₄O₄S^(1-)*Na⁽¹⁺⁾ 
• 954146-99-7 5-(4-chloro-phenyl)-1-[3-(2,5-dimethyl-pyrrole-1-sulfonyl)-phenyl]-6-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 954147-00-3 6-[4-(5-amino-pyridin-2-yl)-phenyl]-5-(4-chloro-phenyl)-1-[3-(2,5-dimethyl-pyrrole-1-sulfonyl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 954146-85-1 N-(3-{5-(4-chloro-phenyl)-4-oxo-6-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-4,5-dihydro-pyrazolo[3,4-d]pyrimidin-1-yl}-phenyl)-methanesulfonamide 
• 954146-97-5 3-{5-(4-chloro-phenyl)-4-oxo-6-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-4,5-dihydro-pyrazolo[3,4-d]pyrimidin-1-yl}-benzenesulfonamide 
• 954146-66-8 C₂₉H₂₇BClN₅O₅S 
• 954146-74-8 N-(3-{1-(4-chloro-phenyl)-6-oxo-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1,6-dihydro-purin-9-yl}-phenyl)-methanesulfonamide 
• 954146-88-4 1-(4-chloro-phenyl)-9-(3-methanesulfonyl-phenyl)-2-[4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-phenyl]-1,9-dihydro-purin-6-one 
• 954146-96-4 5-(4-chloro-phenyl)-1-(3-methane-sulfonyl-phenyl)-6-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 954146-48-6 5-(4-chloro-phenyl)-3-methanesulfonyl-1-phenyl-6-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 954146-92-0 3-{1-(4-chloro-phenyl)-6-oxo-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1,6-dihydro-purin-9-yl}-benzonitrile 
• 954146-98-6 6-(4-bromo-phenyl)-5-(4-chloro-phenyl)-1-[3-(2,5-dimethyl-pyrrole-1-sulfonyl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 954146-76-0 3-{5-(4-chloro-phenyl)-4-oxo-6-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-4,5-dihydro-pyrazolo[3,4-d]pyrimidin-1-yl}-benzonitrile 
• 954146-83-9 C₂₅H₁₉BrClN₅O₅S₂ 

Relevant articles and documents

Direct Amidation of Carboxylic Acids with Nitroarenes

N-Aryl amides are an important class of compounds in pharmaceutical and agrochemical chemistry. Rapid and low-cost synthesis of N-aryl amides remains in high demand. Herein, we disclose an operationally simple process to access N-aryl amides directly from readily available nitroarenes and carboxylic acids as coupling substrates. This method involves the in situ activation of carboxylic acids to acyloxyphosphonium salt for one-pot amidation, without the need for isolation of the corresponding synthetic intermediates. Furthermore, the ease of preparation and workup allow the quick and efficient synthesis of a wide range of N-aryl amides, including several amide-based druglike and agrochemical molecules.

Sulfate Radical Anion (SO4?-) Mediated C(sp3)-H Nitrogenation/Oxygenation in N-Aryl Benzylic Amines Expanded the Scope for the Synthesis of Benzamidine/Oxazine Heterocycles

A transition-metal-free, K2S2O8-mediated intramolecular oxidative nitrogenation/oxygenation of C(sp3)-H in N-aryl benzylic amines followed by oxidation at the benzylic center has been developed for the synthesis of benzamidine/benzoxazine heterocycles, providing an expedient access to quinazolin-4(3H)-ones, N-aryl-2-arylbenzimidazoles, and 4H-3,1-benzoxazin-4-ones. A considerable amount of work dealing with the mechanistic study to understand the crucial intramolecular cyclization step largely favors an iminium ion as the key intermediate.

AZOLOPYRIMIDINES AS INHIBITORS OF CANNABINOID 1 ACTIVITY

The invention provides compounds of formula (Ia), (Ic), (Ig) and (Ik), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).