213547-85-4

Usage

Type of compound

nitro-substituted aromatic compound with a vinyl ether functional group

Usage

reagent in organic synthesis, building block for polymers, precursor in pharmaceuticals and agrochemicals, potential use in dyes and pigments

Hazards

may pose hazards to human health and the environment if not properly managed

Upstream product

• 619-73-8 4-nitrobenzyl chloride 
• 111-34-2 -butyl vinyl ether 
• 109-92-2 ethyl vinyl ether 

Downstream Products

• 1603818-52-5 dimethyl (2R,4S)-4-(2,5-dioxopyrrolidin-1-yl)-2-((4-nitrobenzyl)oxy)cyclopentane-1,1-dicarboxylate 
• 213548-40-4 2'-O-[1-(4-nitrobenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 

Relevant academic research and scientific papers

Dynamic kinetic asymmetric [3 + 2] annulation reactions of aminocyclopropanes

We report the first example of a dynamic kinetic asymmetric [3 + 2] annulation reaction of aminocyclopropanes with both enol ethers and aldehydes. Using a Cu catalyst and a commercially available bisoxazoline ligand, cyclopentyl- and tetrahydrofurylamines were obtained in 69-99% yield and up to a 98:2 enantiomeric ratio using the same reaction conditions. The method gives access to important enantio-enriched nitrogen building blocks for the synthesis of bioactive compounds.

Acetals as New 2′-O-Protecting Functions for the Synthesis of Oligoribonucleotides: Synthesis of Uridine Building Blocks and Evaluation of Their Relative Acid Stability

A broad variety of new acyclic vinyl ethers (see 6-41) have been synthesized via the vinyl-interchange reaction of ethyl vinyl ether at room temperature using mercury(II) trifluoroacetate as a highly efficient catalyst. The appropriate vinyl ethers were r