213554-70-2Relevant academic research and scientific papers
Non-steroidal anti-inflammatory agents: Synthesis of novel benzopyrazolyl, benzoxazolyl and quinazolinyl derivatives of 4(3 H)- quinazolinones
Bekhit,Khalil
, p. 539 - 543 (2007/10/03)
Four novel series of 4(3 H)-quinazolinone derivatives have been synthesized by cyclization of the intermediate 3-aryl-2-(6-aryl-2-cyclohexen- 1-on-5-yl)-4(3H)-quinazolinones 3a-f with hydrazine, phenylhydrazine, hydroxylamine and thiourea. The products are 3-aryl-2-(6-aryl-3-methyl-1H- 4,5-dihydrobenzo[d]pyrazol-4-yl)-4(3H)-quinazolinones 4a-f; 3-aryl-2-(6- aryl-3-methyl-1-phenyl-1 H-4,5-dihydrobenzo[d]pyrazol-4-yl)-4(3H)- quinazolinones 4g-1; 3-aryl-2-(6-aryl-3-methyl-4,5-dihydrobenzo[d]-1,2- oxazol-4-yl)-4(3 H)-quinazolinones 5a-f, and 3-aryl-2-(7-aryl-4-methyl-5,6- dihydro-2(1 H)thioxoquinazolin-5-yl)-4(3H)-quinazolinones 6a-f. Some of these compounds showed anti-inflammatory activity comparable to or higher than that of the reference compound proquazone.
