213603-12-4Relevant articles and documents
Asymmetric Hydrogenation of In Situ Generated Isochromenylium Intermediates by Copper/Ruthenium Tandem Catalysis
Miao, Tingting,Tian, Zi-You,He, Yan-Mei,Chen, Fei,Chen, Ya,Yu, Zhi-Xiang,Fan, Qing-Hua
supporting information, p. 4135 - 4139 (2017/04/03)
The first asymmetric hydrogenation of in situ generated isochromenylium derivatives is enabled by tandem catalysis with a binary system consisting of Cu(OTf)2 and a chiral cationic ruthenium–diamine complex. A range of chiral 1H-isochromenes were obtained in high yields with good to excellent enantioselectivity. These chiral 1H-isochromenes could be easily transformed into isochromanes, which represent an important structural motif in natural products and biologically active compounds. The chiral induction was rationalized by density functional theory calculations.