213620-11-2

Upstream product

• 213620-10-1 2,2'-di-O-allyl-4,6:4',6'-di-O-benzylidene-3,3'-di-O-methyl-α,α-trehalose 
• 18929-82-3 4,6;4',6'-di-O-benzylidene-α,α-D-trehalose 
• 74-88-4 methyl iodide 
• 99-20-7 TREHALOSE 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 127072-90-6 2,2'-di-O-allyl-4,6:4',6'-di-O-benzylidene-α,α-trehalose 

Relevant academic research and scientific papers

Novel Disaccharide Chiral Ligands Derived from α,α-Trehalose and Their Applications to Asymmetric Hydrogenation of Enamides

New chiral diphosphinite ligands such as 4,6 : 2′,3′ : 4′,6′-tri-O-cyclohexylidene-2,3-di-O-diphenylphosphino-α, αtrehalose (1), 3,3′-di-O-benzyl-4,6 : 4′,6′-di-O-benzylidene-2,2′-di-O-diphenylphosphino-α, α-trehalose (2), 4,6 : 4′,6′-di-O-benzylidene-2,2′-di-O-diphenylphosphino-3,3′- di-O-methyl-α,α-trehalose (3), and 2,2′-di-O-benzyl-4,6 : 4′,6′-di-O-benzylidene-3,3′-di-O-diphenylphosphino-α, α-trehalose (4) were prepared from α,α-trehalose which is an inexpensive natural reserve sugar. These ligands work as chiral ligands for Rh-catalyzed hydrogenation of α-acetamidoacrylic and cinnamic acid derivatives to afford both enantiomers of amino acids up to 84%ee (S) and 72%ee (R).