21363-18-8

Basic information

• Product Name: viminol
• Synonyms: viminol;1-(o-Chlorobenzyl)-α-[(di-sec-butylamino)methyl]-1H-pyrrole-2-methanol;Diviminol;Z-424;1-(2-Chlorobenzyl)-alpha-((di-sec-butylamino)methyl)pyrrol-2-methanol;1-(alpha-(N-o-Chlorobenzyl)pyrryl)-2-di-sec-butylaminoethanol;1-(o-Chlorobenzyl)-alpha-((di-sec-butylamino)methyl)pyrrole-2-methanol;1H-Pyrrole-2-methanol, alpha-((bis(1-methylpropyl)amino)methyl)-1-((2-chlorophenyl)methyl)-
• CAS NO: 21363-18-8
• Molecular Formula: C₂₁H₃₁ClN₂O
• Molecular Weight: 362.942
• EINECS: 244-347-8
• Mol File: 21363-18-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: bp0.1 mm 160-165°
• Flash Point: 148.1°C
• Appearance: /
• Density: 1.07g/cm³
• Vapor Pressure: 0.000125mmHg at 25°C
• Refractive Index: 1.544
• PKA: 14.38±0.20(Predicted)
• CAS DataBase Reference: viminol(CAS DataBase Reference)
• NIST Chemistry Reference: viminol(21363-18-8)
• EPA Substance Registry System: viminol(21363-18-8)

Safety Data

• Hazardous Substances Data: 21363-18-8(Hazardous Substances Data)

Usage

Originator

Dividol ,Zambon ,Italy ,1974

Manufacturing Process

10 g (0.0278 mol) of 1-(o-chloro)-benzyl-2-di-sec-butylaminoacetyl-pyrrole and 300 ml of anhydrous diethyl ether are placed in a 500 ml four-necked flask with a mercury-sealed stirrer, a thermometer, a dropping funnel and a reflux condenser topped with a tube containing anhydrous calcium chloride. The solution is stirred and a mixture of 1g (0.0264 mol) of lithium aluminum hydride in 20 ml of diethyl ether is added slowly through the dropping funnel at such a rate that the solvent refluxes gently without external heating. When the addition is complete and the initial reaction subsides, the mixture is stirred and heated at gentle reflux for two hours. The mixture is cooled and the excess of lithium aluminum hydride is decomposed with cracked ice. The water layer is separated and washed with diethyl ether. The combined ether extracts are dried over anhydrous magnesium sulfate and the solvent is removed by distillation under reduced pressure. Yield, 8.8 g; boiling point, 160°C to 165°C/0.1 mm Hg.

Therapeutic Function

Analgesic

InChI:InChI=1/C21H31ClN2O/c1-5-16(3)24(17(4)6-2)15-21(25)20-12-9-13-23(20)14-18-10-7-8-11-19(18)22/h7-13,16-17,21,25H,5-6,14-15H2,1-4H3

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