21363-69-9

Upstream product

• 24686-78-0 1-Benzoyl-4-piperidone 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 54108-67-7 N-benzoyl-4-(carbethoxymethyl)piperidine 
• 911228-57-4 C₂₂H₂₅NO₃S 
• 911228-58-5 C₂₀H₁₉NO₄S 
• 136080-61-0 1'-benzoyl-3,4-dihydro-spiro[2H-1-benzothiopyran-2,4'-piperidin]-4-one 
• 40110-55-2 ethyl 2-(1-benzylpiperidine-4-ylidene)acetate 
• 120014-22-4 (1-benzoylpiperidine-4-yl)acetanilide 
• 56772-11-3 (1-benzoylpiperidin-4-yl)acetic acid 
• 30338-60-4 6-benzoyl-1-oxa-6-aza-spiro[2.5]octane-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE

Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.

Preparation of cinchona alkaloid intermediates

4-[3-(3-vinyl-1-acetyl-4-piperidyl)-1-propenyl]-6-methoxyquinoline, the corresponding epoxide and related compounds, useful in the synthesis of Cinchona alkaloids, are prepared by introducing an ylid group in the 4-position of a suitably substituted quinoline and reacting this ylid with an N-acetyl-4-piperidineacetaldehyde.