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Relevant academic research and scientific papers

Synthesis, structure, antioxidation, and DNA-binding studies of a binuclear ytterbium(III) complex with bis(N-salicylidene)-3-oxapentane-1,5-diamine

A new complex of ytterbium(III) nitrate with bis(N-salicylidene)-3-oxapentane-1,5-diamine (H2L), with the composition Yb2(L)2(NO3)2·2H2O, was synthesized and characterized by physic-chemical and spectroscopic methods. The crystal structure of the ytterbium(III) complex has been determined by single-crystal X-ray diffraction. It reveals a centrosymmetric binuclear neutral entity where Yb(III) metal centers are bridged by two phenoxo oxygen atoms. Electronic absorption titration spectra, ethidium bromide displacement experiments, and viscosity measurements indicate that both the ligand and the Yb(III) complex can bind calf thymus DNA, presumably via a groove binding mechanism. Furthermore, the antioxidant activities of the Yb(III) complex were determined by a superoxide and hydroxyl radical scavenging method in vitro, which indicates that it is a scavenger for OH and O2 - radicals.

Study on synthesis, crystal structure, antioxidant and DNA-binding of mono-, di- and poly-nuclear lanthanides complexes with bis(N-salicylidene)-3- oxapentane-1,5-diamine

A Schiff base ligand bis(N-salicylidene)-3-oxapentane-1,5-diamine H 2L have been prepared. Reaction of the shape-specific designed ligand with Ln(NO3)36H2O afforded three novel complexes, namely, Sm(L)(NO3)(DMF)(H2O) 1, [Eu(H 2L)2(NO3)3]n 2 and Tb2(L)2(NO3)2 3. The ligand and complexes were characterized by elemental analysis, UV-Vis, IR, NMR spectroscopy and X-ray crystallography. It is noteworthy that the complexes demonstrate three different types of the structure which changed according to the charge density and acidity of the lanthanide. Complex 1 is a discrete mononuclear species that Sm(III) ion is nine-coordinated in the structure and forming a distorted tricapped trigonal prism geometry. Complex 2 is possessed a 1-D ribbon framework constructed from an extended array of ten-coordinated Eu3+ centers and the Schiff base ligands. Complex 3 is revealed as a centrosymmetric binuclear neutral entity, in which Tb(III) ion is eight-coordinated with the coordination surround of distorted square antiprism geometry. In order to explore the relationship between the structure and biological properties, the DNA-binding properties have been investigated by electronic absorption, fluorescence, and viscosity measurements. The results suggest that the ligand and complexes bind to DNA via groove modes. The intrinsic binding constants Kb of the complexes 1-3 are (1.19 ± 0.112) × 10 5, (4.22 ± 0.086) × 104 and (3.89 ± 0.104) × 104 M-1 respectively. Moreover, the antioxidant activity experiments show that these compounds also exhibit good antioxidant activities against OH and O2- in vitro studies.

Design, synthesis and spectroscopic characterization of mixed N- and O-donor Schiff base ligands (N2O3): Crystal structures of free ligands

Five Schiff base ligands containing the same bridging spacer group but differing in the substituents on the phenyl ring were synthesised and fully characterized by various spectroscopic and analytical techniques. Three of these ligands are new and all hav

Two Lanthanide(III) Complexes based on the Schiff Base N,N'- Bis(salicylidene)-1,5-diamino-3-oxapentane: Synthesis, Characterization, DNA-binding Properties, and Antioxidation

The Schiff base N,N'-bis(salicylidene)-1,5-diamino-3-oxapentane (H 2L) and its lanthanide(III) complexes, PrL(NO3)(DMF) (H2O) (1) and Ho2L2(NO3) 2·2H2O (2), were synth

Synthesis, crystal structure, DNA-binding properties and antioxidant activities of a lutetium(III) complex with the bis(N-salicylidene)-3-oxapentane- 1,5-diamine ligand

A Schiff base ligand bis(N-salicylidene)-3-oxapentane-1,5-diamine (H 2L) and its lutetium(III) complex, with composition Lu 2(L)2 (NO3)2, were synthesized and characterized by physico-chemical and spectroscopic methods. The crystal structure of the Lu(III) complex has been determined by single-crystal X-ray diffraction. It reveals a centrosymmetric binuclear neutral entity where Lu(III) metal centers are bridged by two phenoxo oxygen atoms. The DNA-binding properties of the Lu(III) complex were investigated by spectrophotometric methods and viscosity measurements, and the results suggest that the Lu(III) complex binds to DNA via a groove binding mode. Additionally, the antioxidant activity of the Lu(III) complex was determined by the superoxide and hydroxyl radical scavenging methods in vitro, which indicate that it is a scavenger for OH and O2- radicals.

Preparation, structure, DNA-binding properties, and antioxidant activities of a homodinuclear erbium(III) complex with a pentadentate Schiff base ligand

An erbium (III) complex of a pentadentate Schiff base ligand [(NO 3)Er(μ-L)2Er(NO3)].2H2O [H 2L=bis(N-salicylidene)-3- oxapentane-1,5-diamine] has been synthesised, characterised and its structure confirmed by X-ray crystallography. H2L and the Er(III) complex both bind to DNA via a groove binding mode, and the Er(III) complex binds to DNA more strongly than H2L. The complex shows strong scavenging effects for hydroxyl radicals (OH·) and superoxide radicals (O2-·).

Synthesis, crystal structure, antioxidation and DNA-binding properties of a dinuclear copper(II) complex with bis(N-salicylidene)-3-oxapentane-1,5-diamine

A Schiff base bis(N-salicylidene)-3-oxapentane-1,5-diamine (H2L) and its Cu(II) complex, [Cu2(L)2]·CHCl3, have been synthesized and characterized by physicochemical and spectroscopic methods. Single-crystal X-ray analysis revealed that the complex is a centrosymmetric binuclear neutral entity, in which Cu(II) is a five-coordinate in a distorted trigonal bipyramidal geometry. The DNA-binding properties of the free ligand and the complex have been investigated by electronic absorption, fluorescence, and viscosity measurements. The results suggest that the H2L and the complex to DNA via the intercalation mode and the binding affinity of the complex were higher than that of the H2L. The intrinsic binding constants Kb of the ligand and the complex are 2.2 × 104 and 2.7 × 104 M-1, respectively. Antioxidant assay in vitro shows the Cu(II) complex possesses significant antioxidant activities and better scavenging activity than the H2L and other antioxidants.

Training a Constitutional Dynamic Network for Effector Recognition: Storage, Recall, and Erasing of Information

Constitutional dynamic libraries (CDLs) of hydrazones, acylhydrazones, and imines undergo reorganization and adaptation in response to chemical effectors (herein metal cations) via component exchange and selection. Such CDLs can be subjected to training by exposition to given effectors and keep memory of the information stored by interaction with a specific metal ion. The long-term storage of the acquired information into the set of constituents of the system allows for fast recognition on subsequent contacts with the same effector(s). Dynamic networks of constituents were designed to adapt orthogonally to different metal cations by up- and down-regulation of specific constituents in the final distribution. The memory may be erased by component exchange between the constituents so as to regenerate the initial (statistical) distribution. The libraries described represent constitutional dynamic systems capable of acting as information storage molecular devices, in which the presence of components linked by reversible covalent bonds in slow exchange and bearing adequate coordination sites allows for the adaptation to different metal ions by constitutional variation. The system thus performs information storage, recall, and erase processes.

A Schiff base bis(N-salicylidene)-3-oxapentane-1,5-diamine and its yttrium(III) complex: Synthesis, crystal structure, DNA-binding properties, and antioxidant activities

A Schiff base bis(N-salicylidene)-3-oxapentane-1,5-diamine (H2L) and its yttrium(III) (Y(III)) complex, Y2L2(NO 3)2?2H2O, have been synthesized and characterized by physico-chemical and spectroscopic methods. The crystal structure of the Y(III) complex has been determined by single-crystal X-ray diffraction, revealing a centrosymmetric binuclear neutral entity where Y(III) centers are bridged by two phenoxo oxygens. The DNA-binding properties of the Schiff base H2L and the Y(III) complex were investigated by spectrophotometric methods and viscosity measurements. The results suggest that ligand H2L and Y(III) complex both bind to DNA via groove binding, and the Y(III) complex binds to DNA more strongly than H2L. The antioxidant activity of the Y(III) complex was determined by superoxide and hydroxyl radical-scavenging method in vitro, which indicates that Y(III) complex scavenges OH? and O2 radicals.