213666-98-9Relevant academic research and scientific papers
Novel complex n-heterocycles via intramolecular 1,5-electrocyclizations: l,2,4,4a,5,5a,10-octahydropyrido[4",3":2',3']cyclobuta[1',2':4,5] pyrrolo[2,3-b]pyridines
Walter, Harald,Sundermann, Garsten
, p. 1581 - 1591 (1998)
The synthesis of 2-amino-3-isopropenylpyridine (5) and 2-amino-5-chloro-3-isopropenylpyridine (6) and their toluenesulfonic acid catalyzed reactions in refluxing toluene with some 1-substituted piperidin-4-ones are described. The toluenesulfonic acid cata
Nickel/Photo-Cocatalyzed Asymmetric Acyl-Carbamoylation of Alkenes
Fan, Pei,Lan, Yun,Zhang, Chang,Wang, Chuan
, p. 2180 - 2186 (2020/03/03)
An unprecedented asymmetric acyl-carbamoylation of pendant alkenes tethered on aryl carbamic chlorides with both aliphatic and aromatic aldehydes has been developed via the cooperative catalysis of a chiral nickel-PHOX complex and tetrabutylammonium decatungstate. This reaction represents the first example of merging hydrogen-atom-transfer photochemistry and asymmetric transition metal catalysis in difunctionalization of alkenes. Using this protocol, a variety of oxindoles bearing a challenging quaternary stereogenic center are furnished under mild conditions in highly enantioselective manner.
KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
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Paragraph 0652, (2019/11/19)
Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
