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Usage

Uses

Used in Pharmaceutical Industry:
2'-Bromo-N,N-dimethyl-[1,1'-biphenyl]-2-amine is used as a reagent or intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a valuable component in the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical industry, 2'-Bromo-N,N-dimethyl-[1,1'-biphenyl]-2-amine is utilized as a reagent or intermediate in the production of agrochemicals. Its properties make it suitable for the synthesis of pesticides, herbicides, and other agricultural chemicals.
Used in Materials Science:
2'-Bromo-N,N-dimethyl-[1,1'-biphenyl]-2-amine is also used in materials science for the development of new materials with specific properties. Its unique structure can contribute to the creation of advanced materials for various applications, such as in electronics, coatings, and polymers.

Upstream product

• 50-00-0 formaldehyd 
• 73006-87-8 2'-bromo-N-methyl-[1,1'-biphenyl]-2-amine 
• 698-00-0 2-bromo-N,N-dimethylaniline 
• 583-53-9 2,3-dibromobenzene 
• 583-55-1 1-Bromo-2-iodobenzene 
• 89291-23-6 2-(N,N-dimethylamino)phenylboronic acid 

Downstream Products

• 1326737-76-1 2-dimesitylboryl-2'-(N,N-dimethylamino)biphenyl 
• 224311-49-3 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine 

Relevant academic research and scientific papers

Aryl radical-induced desulfonylative: Ipso -substitution of diaryliodonium salts: An efficient route to sterically hindered biarylamines

By using vicinal aryl sulfonamide substituted diaryliodonium salts, a cascade of desulfonylation/aryl migration was promoted by triethylamine in the synthesis of sterically hindered biarylamines, which operated via a radical-induced reaction pathway. The products were readily converted into a variety of important synthons. Furthermore, coupling reactions of N-methyl biarylamine and 1,6-dibromopyrene provided a potentially attractive molecule in OLEDs.

Palladium-Catalyzed Carboamination of Allylic Alcohols Using a Trifluoroacetaldehyde-Derived Tether

The selective palladium-catalyzed carboamination of allylic alcohols is reported on the basis of the use of an easily introduced trifluoroacetaldehyde-derived tether. Aminoalkynylation reactions were realized using alkynyl bromides and commercially available phosphine ligands. For aminoarylations, a new biaryl phosphine ligand, "Fu-XPhos", was introduced to overcome a competitive Heck pathway. The carboamination products were obtained in high yields and diastereoselectivity. The tether could be easily removed to give value-added amino alcohol building blocks.

Synthesis of novel fused azecine ring systems through application of the tert-amino effect

Novel fused azecine ring systems were synthesized via the microwave-assisted thermal isomerization of terphenyl or biphenyl-pyridazine compounds possessing a vinyl and a tert-amino group, through application of a new extension of the tert-amino effect. Substrates for the ring closure were prepared from ortho-dihalobenzene or pyridazinone by consecutive Suzuki couplings with ortho-sec-amino- and formylphenylboronic acids, followed by Knoevenagel condensation of the aldehydes obtained.

Probing the importance of the hemilabile site of bis(phosphine) monoxide ligands in the copper-catalyzed addition of diethylzinc to N-phosphinoylimines: Discovery of new effective chiral ligands

(Chemical Equation Presented) The hemilabile ligand Me-DuPHOS(O) 2 has proven to be a successful ligand for the copper-catalyzed addition of diethylzinc to N-phosphinoylimines. The corresponding α-chiral amines were obtained in high yields (80-98%) and enantiomeric ratios (19.0:1 to 99.0:1 er). Furthermore, this Cu?2 catalytic system has been shown to be effective in the addition of diethylzinc to nitroalkenes and in the reduction of β,β-disubstituted vinyl phenyl sulfones. This paper describes a general structure/selectivity study in which the three ligand subunits (chiral phospholane-linker-labile coordinating group (Z)) are systematically modified and tested in the copper-catalyzed addition of diethylzinc to the N-phosphinoylimine 1 derived from benzaldehyde. This study led to the discovery of a new class of effective chiral ligands that combine a chiral phospholane unit and an achiral phosphine oxide.