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2137047-43-7

2137047-43-7

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2137047-43-7 Usage

Uses

VU 6005649, is a novel mGlu7/8 receptor agonist with excellent CNS penetration (Kp 1.9-5.8 and Kp,uu 0.4-1.4).

Check Digit Verification of cas no

The CAS Registry Mumber 2137047-43-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,1,3,7,0,4 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2137047-43:
(9*2)+(8*1)+(7*3)+(6*7)+(5*0)+(4*4)+(3*7)+(2*4)+(1*3)=137
137 % 10 = 7
So 2137047-43-7 is a valid CAS Registry Number.

2137047-43-7Downstream Products

2137047-43-7Relevant articles and documents

Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines

Abe, Masahito,Seto, Mabel,Gogliotti, Rocco G.,Loch, Matthew T.,Bollinger, Katrina A.,Chang, Sichen,Engelberg, Eileen M.,Luscombe, Vincent B.,Harp, Joel M.,Bubser, Michael,Engers, Darren W.,Jones, Carrie K.,Rodriguez, Alice L.,Blobaum, Anna L.,Conn, P. Jeffrey,Niswender, Colleen M.,Lindsley, Craig W.

, p. 1110 - 1115 (2017)

Herein, we report the structure-activity relationships within a series of mGlu7 PAMs based on a pyrazolo[1,5-a]pyrimidine core with excellent CNS penetration (Kps > 1 and Kp,uus > 1). Analogues in this series proved to dis

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