213744-43-5Relevant academic research and scientific papers
PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS
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, (2008/06/13)
Compounds of formula I including pharmaceutically acceptable salts thereof in which R1 represents hydrogen, 2-phenyl-1,3-dioxan-5-yl, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C5-7 cycloalkenyl group or an (optionally substituted phenyl)C1-6 alkyl gr
Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I
Arnold, Lee D.,Calderwood, David J.,Dixon, Richard W.,Johnston, David N.,Kamens, Joanne S.,Munschauer, Rainer,Rafferty, Paul,Ratnofsky, Sheldon E.
, p. 2167 - 2170 (2007/10/03)
Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are potent and selective inhibitors of lck in vitro; some compounds are selective for lck over src. Data are shown for two compounds demonstrating that they are potent and selective in
